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anti-Niemann-Pick Disease, Type C2 (NPC2) Antibodies

NPC2 encodes a protein containing a lipid recognition domain. Additionally we are shipping NPC2 Proteins (15) and NPC2 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPC2 67963 Q9Z0J0
NPC2 10577 P61916
NPC2 286898  
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Top anti-NPC2 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated EIA, WB AP20108PU-N NPC2 antibody staining of Human Testis lysate at 0.5 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated EIA, WB AP23678PU-N NPC2 antibody staining of Mouse Kidney lysate at 0.1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated WB Western Blot analysis of NPC2 expression in transfected 293T cell line by NPC2 MaxPab polyclonal antibody.Lane 1: NPC2 transfected lysate(16.61 KDa).Lane 2: Non-transfected lysate. NPC2 MaxPab polyclonal antibody. Western Blot analysis of NPC2 expression in NIH/3T3. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated IP, ELISA 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Mouse Un-conjugated IP, ELISA Immunoprecipitation of NPC2 transfected lysate using anti-NPC2 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with NPC2 MaxPab rabbit polyclonal antibody. Detection limit for recombinant GST tagged NPC2 is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details

NPC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NPC2 Antibodies

  1. Human Polyclonal NPC2 Primary Antibody for EIA, WB - ABIN498021 : Xu, Farver, Kodukula, Storch: Regulation of sterol transport between membranes and NPC2. in Biochemistry 2008 (PubMed)
    Show all 2 references for ABIN498021

  2. Human Polyclonal NPC2 Primary Antibody for WB - ABIN524003 : Giacomini, Ura, Giolo, Luppi, Martinelli, Garcia, Ricci: Comparative analysis of the seminal plasma proteomes of oligoasthenozoospermic and normozoospermic men. in Reproductive biomedicine online 2015 (PubMed)

More Antibodies against NPC2 Interaction Partners

Mouse (Murine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. These findings show that NPC2 secreted by premalignant lung tumours suppresses immature macrophage-lineage cell recruitment to the microenvironment in a paracrine manner.

  2. Using the inhibitors of cathepsin enzymatic activity, it was found that cathepsins B and L regulate TNF-alpha (show TNF Antibodies) production, the expression and secretion of NPC2 protein, and the mRNA levels of the genes involved in cholesterol trafficking in macrophages.

  3. Npc1 (show NPC1 Antibodies) and npc2 deficiencies result in pulmonary abnormalities observed in human Niemann-Pick type C disease.

  4. This is the first report demonstrating that GNMT (show GNMT Antibodies) plays an important role in regulating cholesterol homeostasis via interaction with NPC2

  5. NPC1 (show NPC1 Antibodies) and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol

  6. In liver, absence of either NPC1 (show NPC1 Antibodies) or NPC2 resulted in similar alterations in the carbohydrate processing of the lysosomal protease, tripeptidyl peptidase I (show TPP1 Antibodies).

  7. The lack of fibronectin (show FN1 Antibodies) did not interfere with reconstruction of collagen fibril organization in response to liver injury.

  8. NPC2 is a positive regulator of biliary cholesterol secretion via stimulation of ABCG5 (show ABCG5 Antibodies)/G8-mediated cholesterol transport.

  9. Studies showed that processing and export of sterol from the late E/L compartment was quantitatively different in mice lacking LAL (show LIPA Antibodies), NPC2, or NPC1 (show NPC1 Antibodies) function.

  10. NPC2 as a novel intracrine/autocrine factor that controls adipocyte differentiation and function

Human Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. Structure of glycosylated NPC1 (show NPC1 Antibodies) luminal domain C reveals insights into NPC2 and Ebola virus interactions

  2. hypothesize that, in part, NPC2 rapidly traffics cholesterol between closely appositioned membranes within the multilamellar interior of late endosomal/lysosomal proteins, ultimately effecting cholesterol egress from this compartment

  3. NPC2 may play an important role in negatively regulate cell proliferation.

  4. heterozygous mutations in the NPC1 (show NPC1 Antibodies)/2 gene might be a risk factor for Alzheimer's disease

  5. Data suggest that in order for the ligand cholesterol to slide from one binding pocket to the other (from NPC2 to NPC1 (show NPC1 Antibodies)), cholesterol undergoes conformational change/isomerization to accommodate the bent transfer pathway between the 2 binding pockets.

  6. Suggest role for mouse epididymal NPC2 in regulating male fertility.

  7. twelve individuals were subsequently confirmed to be NP-C by DNA analysis of NPC1 (show NPC1 Antibodies) and NPC2 genes, with the early infantile form, the late infantile form, the juvenile form, and the adult form

  8. Recombinant NPC2 protein increases triglyceride levels in body fat.

  9. these results suggest that the vitamin A-mediated antimicrobial mechanism against M. tuberculosis requires NPC2-dependent expression and function, indicating a key role for cellular cholesterol regulation in the innate immune response.

  10. The p.Pro120Ser causing mutation in NPC2 observed in the Iranian patients was earlier observed in the only other NPC2 patient reported from the Middle East.

Cow (Bovine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. Data suggest ASM (acid sphingomyelinase (show SMPD1 Antibodies)) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM (show SMPD1 Antibodies) may be crucial for endosomal lipid degradation/sorting.

  2. Data show that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C.

  3. analysis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

  4. The seminal plasma protein, Niemann-Pick C2 protein, is involved in cholesterol and GM1 depletion within detergent-resistant membrane, then leading to membrane redistribution of P25b that occurs in a very rapid and capacitation-independent manner.

  5. NPC2 plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport. Rates of sterol transfer from and between membranes were increased by as much as 2 orders of magnitude by NPC2.

NPC2 Antigen Profile

Protein Summary

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.

Gene names and symbols associated with NPC2

  • Niemann Pick type C2 (Npc2) antibody
  • Niemann-Pick disease, type C2 (NPC2) antibody
  • Niemann-Pick disease, type C2 (Npc2) antibody
  • Niemann-Pick disease, type C2 (npc2) antibody
  • 2700012J19Rik antibody
  • AA408070 antibody
  • AU045843 antibody
  • cb292 antibody
  • CE1 antibody
  • EDDM1 antibody
  • EPI-1 antibody
  • HE1 antibody
  • re1 antibody
  • sb:cb292 antibody

Protein level used designations for NPC2

epididymal secretory protein E1 , mE1 , niemann Pick type C2 protein homolog , Niemann-Pick disease type C2 protein , epididymal protein 1 , human epididymis-specific protein 1 , tissue-specific secretory protein , Niemann Pick type C2 , epididymal secretory protein 1 , EPV20 , 16 kDa secretory protein , 16kDa secretory protein , 16.5 kDa secretory protein

GENE ID SPECIES
67963 Mus musculus
10577 Homo sapiens
286898 Rattus norvegicus
280815 Bos taurus
403920 Canis lupus familiaris
397410 Sus scrofa
450192 Pan troglodytes
282673 Danio rerio
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