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Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Additionally we are shipping NPRL2 Antibodies (81) and many more products for this protein.
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Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.
The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor (show RPTOR Proteins).
NPRL2 mutations are significant cause of focal epilepsy.
NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.
NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.
Decreased expression of NPRL2 is associated with renal cancer.
NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.
Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer.
NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.
Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors.
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
, gene 21 protein
, nitrogen permase homolog
, nitrogen permease regulator 2-like protein
, tumor suppressor candidate 4
, G21 protein
, homologous to yeast nitrogen permease (candidate tumor suppressor)