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Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) Proteins (NPRL2)

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Additionally we are shipping NPRL2 Antibodies (81) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPRL2 56032 Q9WUE4
NPRL2 10641 Q8WTW4
Rat NPRL2 NPRL2 363138  
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Top NPRL2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,045.17
Details

NPRL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) Interaction Partners

Human Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) interaction partners

  1. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.

  2. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor (show RPTOR Proteins).

  3. NPRL2 mutations are significant cause of focal epilepsy.

  4. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.

  5. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.

  6. Decreased expression of NPRL2 is associated with renal cancer.

  7. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.

  8. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer.

  9. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.

  10. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors.

NPRL2 Protein Profile

Protein Summary

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

Gene names and symbols associated with NPRL2

  • nitrogen permease regulator-like 2 (Nprl2)
  • nitrogen permease regulator-like 2 (nprl2)
  • nitrogen permease regulator-like 2 (S. cerevisiae) (NPRL2)
  • nitrogen permease regulator-like 2 (S. cerevisiae) (Nprl2)
  • nitrogen permease regulator-like 2 (S. cerevisiae) (nprl2)
  • 2810446G01Rik protein
  • G21 protein
  • im:6900399 protein
  • NPR2 protein
  • npr2l protein
  • TUSC4 protein
  • zgc:153630 protein

Protein level used designations for NPRL2

NPR2-like protein , gene 21 protein , nitrogen permase homolog , nitrogen permease regulator 2-like protein , tumor suppressor candidate 4 , 2810446G01Rik , G21 protein , homologous to yeast nitrogen permease (candidate tumor suppressor)

GENE ID SPECIES
56032 Mus musculus
379794 Xenopus laevis
10641 Homo sapiens
476614 Canis lupus familiaris
508487 Bos taurus
363138 Rattus norvegicus
559391 Danio rerio
Selected quality suppliers for NPRL2 Proteins (NPRL2)
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