anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Antibodies

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Proteins (17) and NUDT1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
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Top anti-NUDT1 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), SimWes, WB Simple Western: MTH1 Antibody [ABIN151036] - Simple Western lane view shows a specific band for MTH1 in 0.5 mg/ml of A431 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.2 mL Log in to see 7 to 9 Days
$473.81
Details
Human Rabbit Un-conjugated WB Western blot analysis of MTH1 expression in A549 (A), mouse liver (B), rat brain (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of NUDT1 expression in transfected 293T cell line by NUDT1 monoclonal antibody (M02), clone 5F11. Lane 1: NUDT1 transfected lysate(18 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged NUDT1 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-NUDT1 / MTH1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1103348 dilution 1:100. 50 μL Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated ICC, IF, IHC, WB 200 μL Log in to see 6 to 7 Days
$506.80
Details
Human Rabbit Un-conjugated ELISA, WB The NUDT1 Antibody is used in Western blot to detect NUDT-1 in HEK293 cell lysates. 0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: MTH1 Antibody  - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts. Immunocytochemistry/Immunofluorescence: MTH1 Antibody  - Staining of human cell line U-2 OS shows positivity in cytoplasm. Antibody staining is shown in green. 100 μL Log in to see 7 to 9 Days
$439.69
Details
Human Rabbit Un-conjugated IP, WB NUDT1 MaxPab rabbit polyclonal antibody. Western Blot analysis of NUDT1 expression in human kidney. Immunoprecipitation of NUDT1 transfected lysate using anti-NUDT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with NUDT1 MaxPab mouse polyclonal antibody (B01) . 100 μL Log in to see 11 to 12 Days
$418.57
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of NUDT1 expression in transfected 293T cell line by NUDT1 monoclonal antibody (M02), clone 5F11.Lane 1: NUDT1 transfected lysate(18 KDa).Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged NUDT1 is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details

NUDT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NUDT1 Antibodies

  1. Human Polyclonal NUDT1 Primary Antibody for ICC, IF - ABIN151036 : Takeshita, Ogawa, Asamoto, Shirai: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. in Cancer letters 2003 (PubMed)
    Show all 15 references for 151036

More Antibodies against NUDT1 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. MTH1 together with MYH (show MUTYH Antibodies) plays an important role in protection against mutations induced by modified dNTPs during chronic oxidative stress.

  2. Reduced MUTYH (show MUTYH Antibodies), MTH1, and OGG1 (show OGG1 Antibodies) expression and TP53 (show TP53 Antibodies) mutations occur in diffuse-type adenocarcinoma of gastric cardia.

  3. Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp (show ASIP Antibodies)-119 and Asp (show ASIP Antibodies)-120) in its substrate binding pocket

  4. MTH1 inhibition may offer a general approach to treat cancers characterized by deregulated hypoxia signaling or redox imbalance

  5. MTH-1 expression in colorectal cancer cells was upregulated via HIF-1alpha (show HIF1A Antibodies) in response to hypoxic stress, emphasizing the crucial role of HIF-1alpha (show HIF1A Antibodies)-induced MTH-1 in tumor growth.

  6. activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future

  7. a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.

  8. MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.

  9. MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS Antibodies).

  10. Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  2. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  3. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Antigen Profile

Protein Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) antibody
  • Mth1 antibody
  • mutT antibody
  • nudT1 antibody

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
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