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The product of OTUB1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (21) and many more products for this protein.
Showing 10 out of 126 products:
Human Monoclonal OTUB1 Primary Antibody for WB - ABIN393473
Edelmann, Kramer, Altun, Kessler: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion. in The FEBS journal 2010
Show all 5 references for ABIN393473
Cow (Bovine) Polyclonal OTUB1 Primary Antibody for WB - ABIN2787016
Juris, Shah, Shokat, Dixon, Vacratsis: Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. in FEBS letters 2006
OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym (show PTMA Antibodies)
GRAIL (show RNF128 Antibodies) expression is regulated by the IL2 (show IL2 Antibodies)/mTOR (show FRAP1 Antibodies)/Otubain-1 axis in CD4 (show CD4 Antibodies) T cells during Trypanosoma cruzi infection.
Otub1 as a Tau deubiquitinase in vitro and in vivo, involved in formation of pathological Tau forms, including small soluble oligomeric forms
OTUB1 may play an important role in colon cancer development and metastasis.
An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 (show MAPK1/3 Antibodies) phosphorylation, high Ki67 (show MKI67 Antibodies) score, and poorer patient survival.
the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 (show FOXM1 Antibodies) in breast cancer and has a key role in genotoxic agent resistance.
substrate for hydroxylation by FIH (show CASR Antibodies) on N22
Data show that casein kinase 2 (CK2 (show CSNK2A1 Antibodies))-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1.
OTUB1 promoted the metastasis of CRC (show CALR Antibodies) cell lines.
After viral infection, HSCARG (show NMRAL1 Antibodies) interacted with tumor necrosis receptor-associated factor 3 (TRAF3 (show TRAF3 Antibodies)) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3 (show TRAF3 Antibodies).
These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 (show UBE2D1 Antibodies) and the function to suppress it.
OTUB1 enhances TGF-beta (show TGFB1 Antibodies) signaling by inhibiting the ubiquitylation and degradation of active SMAD2 (show SMAD2 Antibodies) and SMAD3 (show SMAD3 Antibodies).
A second role of OTUB1-E2 interactions is to stimulate OTUB1 cleavage of Lys48 polyubiquitin. This stimulation is regulated by the ratio of charged to uncharged E2 and by the concentration of Lys48-linked polyubiquitin and free ubiquitin.
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
ubiquitin thioesterase OTUB1
, OTU domain, ubiquitin aldehyde binding 1
, otubain 1
, Ubiquitin thioesterase OTUB1
, ubiquitin thioesterase otub1
, OTU domain-containing ubiquitin aldehyde-binding protein 1
, deubiquitinating enzyme OTUB1
, ubiquitin-specific-processing protease OTUB1
, OTU-domain Ubal-binding 1
, ubiquitin-specific protease otubain 1