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Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Additionally we are shipping OTUD7B Antibodies (34) and many more products for this protein.
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these data reveal a novel mechanism for the regulation of the expression of HIF2a (show EPAS1 Proteins), demonstrating that the HIF2a (show EPAS1 Proteins) promoter is regulated by E2F1 (show E2F1 Proteins) directly and that Cezanne regulates HIF2a (show EPAS1 Proteins) expression through control of E2F1 (show E2F1 Proteins) levels
Taken together, these results suggest that hepatitis C virus NS5A protein interacts with OTUD7B, thereby modulating its deubiquitinase activity.
Cezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in hepatocellular carcinoma patients.
data suggest that Cezanne is essential for HIF-1alpha (show HIF1A Proteins) protein stability and that loss of Cezanne stimulates HIF-1alpha (show HIF1A Proteins) degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy.
Genome wide association study shows evidence of association between mammographic density and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 (show MTMR11 Proteins) and rs67807996 in gene OTUD7B.
Inflammatory responses to ischemia are controlled by a balance between TRAF6 ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR (show EGFR Proteins) signaling
There is an excessive inflammatory response but insufficient up-regulation of A20 (show TNFAIP3 Proteins) expression in inflammatory bowel disease patients.
DJ-1 (show PARK7 Proteins) enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB (show NFKB1 Proteins).
Cezanne is identified as the first deubiquitinase with Lys11-linkage preference.
These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 (show ZAP70 Proteins) function.
Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-kappaB (show NFKB1 Proteins) activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3 (show TRAF3 Proteins)
Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B.
OTU domain containing 7B
, zinc finger protein Cezanne
, OTU domain-containing protein 7B
, zinc finger, A20 domain containing 1
, cellular zinc finger anti-NF-kappa-B protein
, cellular zinc finger anti-NF-kappaB Cezanne
, zinc finger A20 domain-containing protein 1
, TRAF binding domain containing 2