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Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Additionally we are shipping OTUD7B Proteins (7) and many more products for this protein.
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TRAF2 (show TRAF2 Antibodies) and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 (show CRTC2 Antibodies) signalling
Findings indicated both cezanne-1 and IGF1R (show IGF1R Antibodies) expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R (show IGF1R Antibodies) expression.
expression of OTUD7B and NIK (show MAP3K14 Antibodies) were negatively correlated in non-small cell lung cancer tumor samples. The higher expression of OTUD7B was associated with smaller tumor size, less lymph node metastasis and earlier TNM (show ODZ1 Antibodies) stage. the high expression of OTUD7B was associated with good prognosis of NSCLC patients, and a high OTUD7B/low NIK (show MAP3K14 Antibodies) index can predict even better prognosis. also, OTUD7B is an independent markers of survival.
crystal structures of Cezanne alone and in complex with monoubiquitin and Lys11-linked diubiquitin (show UBD Antibodies), in combination with hydrogen-deuterium exchange mass spectrometry, enable a reconstruction of the enzymatic cycle in great detail
these data reveal a novel mechanism for the regulation of the expression of HIF2a (show EPAS1 Antibodies), demonstrating that the HIF2a (show EPAS1 Antibodies) promoter is regulated by E2F1 (show E2F1 Antibodies) directly and that Cezanne regulates HIF2a (show EPAS1 Antibodies) expression through control of E2F1 (show E2F1 Antibodies) levels
Taken together, these results suggest that hepatitis C virus NS5A protein interacts with OTUD7B, thereby modulating its deubiquitinase activity.
Cezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in hepatocellular carcinoma patients.
data suggest that Cezanne is essential for HIF-1alpha (show HIF1A Antibodies) protein stability and that loss of Cezanne stimulates HIF-1alpha (show HIF1A Antibodies) degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy.
Genome wide association study shows evidence of association between mammographic density and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 (show MTMR11 Antibodies) and rs67807996 in gene OTUD7B.
Inflammatory responses to ischemia are controlled by a balance between TRAF6 ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 (show ZAP70 Antibodies) function.
Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-kappaB (show NFKB1 Antibodies) activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3 (show TRAF3 Antibodies)
DJ-1 (show PARK7 Antibodies) enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB (show NFKB1 Antibodies).
Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B.
OTU domain containing 7B
, zinc finger protein Cezanne
, OTU domain-containing protein 7B
, zinc finger, A20 domain containing 1
, cellular zinc finger anti-NF-kappa-B protein
, cellular zinc finger anti-NF-kappaB Cezanne
, zinc finger A20 domain-containing protein 1
, TRAF binding domain containing 2