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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell.
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These data indicated that a hydrogen bond between Y109 residue and azelaic acid is a major determinant of the Olfr544-azelaic acid interaction and activation.
Data indicate that the hydrophobic core buried between helix 8 and TM1 (show TPM2 Antibodies)-2 of olfactory receptor (mOR (show OPRM1 Antibodies)-S6) is important for the activation of both G protein alpha 15 (Galpha15 (show GNA15 Antibodies)).
Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (show OMP Antibodies) (+) cells of the bladder and thyroid.
The N-terminal hydrophobic core between helix 8 and TM1 (show TPM2 Antibodies)-2 of mOR (show OPRM1 Antibodies)-S6 is important for activation of both Galpha15_olf and Galpha15 (show GNA15 Antibodies).
identification of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation
A network of 8 residues in transmembrane domains III, V, and VI was identified forming part of the ligand binding pocket of MOR42-3
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
, odorant receptor S6
, odorant receptor S79
, olfactory receptor MOR42-3
, olfactory receptor Olr544
, olfactory receptor gene Olr544