anti-Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) Antibodies

OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Additionally we are shipping OLIG2 Proteins (6) and OLIG2 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OLIG2 10215 Q13516
OLIG2 304103  
OLIG2 50913 Q9EQW6
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Top anti-OLIG2 Antibodies at antibodies-online.com

Showing 10 out of 121 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-OLIG2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-OLIG2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of U251 cells using OLIG2 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. 100 μL Log in to see 2 to 3 Days
$430.10
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Immunocytochemistry/Immunofluorescence: Olig2 Antibody [NBP1-28667] - Rat cortical neuroepithelial cells with anti-Olig2 (red). The cells were treated with basic FGF for 30 hours prior to staining (this induces Olig2 expression in these primary cells). 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to OLIG2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to OLIG2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Mouse Rabbit Un-conjugated WB OLIG2 Antibody (Center)  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the OLIG2 antibody detected the OLIG2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$423.50
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

OLIG2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-OLIG2 Antibodies

  1. Human Polyclonal OLIG2 Primary Antibody for ICC, IF - ABIN447418 : Kolenda-Roberts, Harris, Singletary, Hardisty: Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat. in Toxicologic pathology 2012 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal OLIG2 Primary Antibody for ICC, IHC - ABIN969331 : Bonnet-Dupeyron, Combes, Boespflug-Tanguy, Vaurs-Barrière: Absence of OLIG2 mutations in patients presenting with a severe Pelizaeus-Merzbacher-like leukodystrophy associated with motor neuron dysfunction. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal OLIG2 Primary Antibody for IHC, IHC (fro) - ABIN447523 : Nijland, Michailidou, Witte, Mizee, van der Pol, van Het Hof, Reijerkerk, Pellerin, van der Valk, de Vries, van Horssen: Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. in Glia 2014 (PubMed)

  4. Human Monoclonal OLIG2 Primary Antibody for IF, IHC (p) - ABIN523613 : Libard, Popova, Amini, Kärjä, Pietiläinen, Hämäläinen, Sundström, Hesselager, Bergqvist, Ekman, Zetterling, Smits, Nilsson, Pfeifer, de Ståhl, Enblad, Ponten, Alafuzoff: Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade. in PLoS ONE 2014 (PubMed)

  5. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777314 : Mitkus, Hyde, Vakkalanka, Kolachana, Weinberger, Kleinman, Lipska: Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. in Schizophrenia research 2007 (PubMed)
    Show all 2 Pubmed References

  6. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777565 : Cowen, Green: The Kallmann's syndrome variant (KSV) model of the schizophrenias. in Schizophrenia research 1993 (PubMed)
    Show all 2 Pubmed References

  7. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777566 : Sun, Hafler, Kaing, Kitada, Ligon, Widlund, Yuk, Stiles, Rowitch: Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. in Developmental biology 2006 (PubMed)

More Antibodies against OLIG2 Interaction Partners

Human Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 (show SIGLEC8 Antibodies) mRNA and protein.

  2. Data indicate that transcription factors Sox10 (show SOX10 Antibodies) and Olig2 play key roles in oligodendrocytes (OLs) specification.

  3. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs (show GNB5 Antibodies)) and 16 (21.3%) of 75 SVZ type III GBs (show GNB5 Antibodies).

  4. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors

  5. The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population. Thus, OLIG2 might serve as a potential target for OCD treatment

  6. The results demonstrate that the expression of Olig2 in dental pulp stem cells reduces the expression of stem cell markers and induces the development of oligodendrocyte progenitors.

  7. High Olig2 expression is associated with oligodendrogliomas.

  8. OLIG2 is the most specific GSC (show GSC Antibodies) marker.

  9. Our study suggests that CGT (show UGT8 Antibodies) expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2 (show Nkx2-2 Antibodies), providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.

  10. Authors investigated the role of Pten (show PTEN Antibodies) in these two critical cellular compartments in adult and developing brains using methods for activation or suppression of PI3K (show PIK3CA Antibodies) signaling in glial and neuronal progenitors expressing Olig2.

Zebrafish Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.

  2. Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.

  3. By cooperating with Shh (show SHH Antibodies), FGF-receptor (show FGFR2 Antibodies) signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.

  4. Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.

  5. Olig2 is required for repression of iro3 (show IRX3 Antibodies) expression in the progenitor domain of ventral spinal cord

  6. data indicate that Hedgehog (show SHH Antibodies) & Wnt (show WNT2 Antibodies) work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog (show SHH Antibodies) limits the range of Wnt (show WNT2 Antibodies) signaling, which is necessary for olig2(+) neuron development

  7. commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1

Mouse (Murine) Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1 (show OLIG1 Antibodies)&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.

  2. Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 (show GPR17 Antibodies) locus

  3. Brg1 (show SMARCA4 Antibodies) represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation

  4. Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR (show PDGFRB Antibodies)) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR Antibodies)) upregulation.

  5. This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome

  6. OLIG2 is a multifunctional regulator of neural stem cell self-renewal

  7. Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5

  8. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro.

  9. This study demonstrated that that OLIG2 overexpression in oligodendrocyte progenitor cells might be a possible therapeutic mechanism for enhancing myelin repair.

  10. Results from expression pattern suggests that Olig2 may have an important role in the early stage of Purkinje cell development.

OLIG2 Antigen Profile

Protein Summary

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14\;21)(q11.2\;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Gene names and symbols associated with OLIG2

  • oligodendrocyte transcription factor 4 (olig4) antibody
  • oligodendrocyte lineage transcription factor 2 (OLIG2) antibody
  • oligodendrocyte lineage transcription factor 2 (LOC100347256) antibody
  • oligodendrocyte lineage transcription factor 2 (Olig2) antibody
  • oligodendrocyte lineage transcription factor 2 (olig2) antibody
  • oligodendrocyte transcription factor 2 (Olig2) antibody
  • oligodendrocyte transcription factor 3 (OLIG3) antibody
  • AI604895 antibody
  • Bhlhb1 antibody
  • bHLHe19 antibody
  • MGC89336 antibody
  • Olg-2 antibody
  • OLIG2 antibody
  • olig3.2 antibody
  • Oligo2 antibody
  • PRKCBP2 antibody
  • RACK17 antibody
  • RK17 antibody
  • wu:fc64g09 antibody

Protein level used designations for OLIG2

oligodendrocyte transcription factor 4 , oligodendrocyte transcription factor 3 , oligodendrocyte lineage transcription factor 2 , basic domain, helix-loop-helix protein, class B, 1 , class B basic helix-loop-helix protein 1 , class E basic helix-loop-helix protein 19 , human protein kinase C-binding protein RACK17 , oligodendrocyte transcription factor 2 , oligodendrocyte-specific bHLH transcription factor 2 , protein kinase C-binding protein 2 , bHLH transcription factor Olig2 , oligo2

GENE ID SPECIES
734024 Xenopus (Silurana) tropicalis
749928 Pan troglodytes
100137242 Papio anubis
100347256 Oryctolagus cuniculus
10215 Homo sapiens
539695 Bos taurus
304103 Rattus norvegicus
325288 Danio rerio
50913 Mus musculus
428612 Gallus gallus
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