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Binds collagen fibrils (By similarity).. Additionally we are shipping OPTC Kits (8) and OPTC Proteins (5) and many more products for this protein.
Showing 10 out of 15 products:
Dog (Canine) Polyclonal OPTC Primary Antibody for WB - ABIN2786017
Kumar, Basavaraj, Gupta, Qamar, Ali, Bajaj, Ramesh, Prakash, Shetty, Dorairaj: Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. in Molecular vision 2007
opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins.
VEGF (show VEGFA Antibodies) and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2 (show MMP2 Antibodies).
localization in the human eye and genetic screen of opticin
OPTC is a candidate gene for primary open-angle glaucoma
OPTC and EPYC (show EPYC Antibodies) are unlikely to play a major role in high myopia.
opticin is a stable dimer in solution [OPTC, opticin]
Binds collagen fibrils (By similarity).
, small leucine-rich repeat protein
, dermatan sulfate proteoglycan 3