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TP53AIP1 is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. Additionally we are shipping TP53AIP1 Antibodies (39) and many more products for this protein.
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Data indicate that p53-regulated apoptosis-inducing protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells, arrests cell cycle at S/G2 (show STRN3 Proteins)-M phase, decreases the abilities of invasion and migration and promotes cell apoptosis.
These studies indicate the critical role of p53AIP1 under DNA damaging stresses for cell fate determination in rheumatoid arthritis-fibroblast-like synovioctes containing the p53R248Q mutation.
Apak competes with p53 (show TP53 Proteins) for binding to inhibit p53AIP1 expression.
large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition
p53AIP1 regulates the mitochondrial apoptotic pathway.
The expression of Ki67 (show MKI67 Proteins) and p53 (show TP53 Proteins) in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia.
expression of the p53 (show TP53 Proteins) mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect.
Roscovitine induced up-regulation of p53AIP1 protein and the depolarization of mitochondrial potential.
p53AIP1 gene is important for non-small cell lung cancer progression and may be a possible prognostic marker
Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection.
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
p53-regulated apoptosis-inducing protein 1