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PARG Proteins (PARG)

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Additionally we are shipping PARG Antibodies (37) and PARG Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARG 8505 Q86W56
PARG 26430  
Rat PARG PARG 83507 Q9QYM2
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Top PARG Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Sf-21 Cells Human His tag   2 μg Log in to see 5 to 8 Days

PARG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for PARG Interaction Partners

Human PARG interaction partners

  1. Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX (show H2AFX Proteins) phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.

  2. Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1 (show NDRG1 Proteins)) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.

  3. Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFB signaling.

  4. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.

  5. The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1 (show PARP1 Proteins)/PARG gene expression balance.

  6. PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.

  7. poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.

  8. Therefore, strategies that target PAR (show JTB Proteins) metabolism for the improved treatment of cancer may be required to target PARP-1 (show PARP1 Proteins) and PARG individually in order to optimize cancer cell death.

  9. PARG silencing could inhibit the ability of HUVEC migration and proliferation by downregulating the activity of NF-kappaB (show NFKB1 Proteins) in LoVo cells that in turn decreases angiogenic factors such as VEGF (show VEGFA Proteins), b-FGF, ICAM-1 (show ICAM1 Proteins), MMP-9 (show MMP9 Proteins), as well as phosphorylation of p38 (show CRK Proteins) and ERK (show EPHB2 Proteins).

  10. Silencing of Apoptosis-Inducing factor (show AIFM1 Proteins) and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

Mouse (Murine) PARG interaction partners

  1. This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.

  2. PARG110 knockout retinal explants were highly resistant to cyclic GMP (show NT5C2 Proteins) toxicity.

  3. we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.

  4. PARG release of PAR (show AFG3L2 Proteins) attached to nuclear proteins, followed by ARH3 (show ADPRHL2 Proteins) cleavage of PAR (show AFG3L2 Proteins), is essential in regulating PAR (show AFG3L2 Proteins)-dependent apoptosis-inducing factor (show AIFM1 Proteins) release from mitochondria and parthanatos.

  5. Data indicate that poly(ADP-ribose) glycohydrolase Parg(-/-) cells were more sensitive to gamma-irradiation than poly(ADP-ribose) polymerase-1 Parp-1 (show PARP1 Proteins)(-/-) cells.

  6. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor (show RARA Proteins)-dependent gene expression.

  7. Results demonstrate nuclear AIF (show AIFM1 Proteins) translocation only in PARG-null TS cells, which demonstrates the presence of AIF (show AIFM1 Proteins)-mediated cell death.

  8. PARP-1 (show PARP1 Proteins)/PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins

  9. PARG-deficient cells showed a compromised DNA repair and increased genomic instability.

  10. Hydrolysis of PARP (show PARP1 Proteins) requires PARG.

PARG Protein Profile

Protein Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Gene names and symbols associated with PARG Proteins (PARG)

  • poly (ADP-ribose) glycohydrolase (PARG)
  • poly (ADP-ribose) glycohydrolase (Parg)
  • AI413217 protein
  • PARG99 protein

Protein level used designations for PARG Proteins (PARG)

mitochondrial poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase 60 kDa isoform , cytosolic poly(ADP-ribose) glycohydrolase , mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform

8505 Homo sapiens
26430 Mus musculus
83507 Rattus norvegicus
281377 Bos taurus
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