PDZ Binding Kinase Proteins (PBK)

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Antibodies (142) and PDZ Binding Kinase Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
Rat PBK PBK 290326  
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Top PDZ Binding Kinase Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$407.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
Details
Insect Cells Human His-GST   100 μg Log in to see 11 to 12 Days
$1,502.67
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$498.21
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$352.75
Details
Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$624.55
Details

PBK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

More Proteins for PDZ Binding Kinase (PBK) Interaction Partners

Human PDZ Binding Kinase (PBK) interaction partners

  1. The role of T-LAK cell-originated protein kinase directly promotes metastasis of colorectal cancer by modulating p53-related protein kinase (show TP53RK Proteins).

  2. TOPK protein and transcriptional levels of FOXM1 (show FOXM1 Proteins) were reduced by TOPK inhibitor treatment.

  3. Results indicate that src (show SRC Proteins)-family kinase (Src (show SRC Proteins)) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK).

  4. Upregulation of proteasome subunit beta type 8 PSMB8 (show PSMB8 Proteins) and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis.

  5. MiR (show MLXIP Proteins)-770-5p and PBK levels were inversely correlated in xenograft model mice.

  6. TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.

  7. Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.

  8. PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

  9. A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.

  10. findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC

Mouse (Murine) PDZ Binding Kinase (PBK) interaction partners

  1. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (show AKT1 Proteins) signaling pathway

  2. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Proteins) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Proteins) signaling pathway.

  3. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  4. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Protein Profile

Protein Summary

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene names and symbols associated with PDZ Binding Kinase Proteins (PBK)

  • PDZ binding kinase (PBK)
  • PDZ binding kinase (pbk)
  • PDZ binding kinase (Pbk)
  • PDZ binding kinase L homeolog (pbk.L)
  • 2810434B10Rik protein
  • AW538537 protein
  • CT84 protein
  • D14Ertd732e protein
  • Nori-3 protein
  • PBK protein
  • SPK protein
  • TOPK protein
  • zgc:92050 protein

Protein level used designations for PDZ Binding Kinase Proteins (PBK)

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPECIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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