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PDZ Binding Kinase Proteins (PBK)

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Antibodies (138) and PDZ Binding Kinase Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
Rat PBK PBK 290326  
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Top PDZ Binding Kinase Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details

PBK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Top referenced PDZ Binding Kinase Proteins

  1. Human PBK Protein expressed in Escherichia coli (E. coli) - ABIN668031 : Dougherty, Garcia, Nakano, Livingstone, Norris, Polakiewicz, Wexler, Sofroniew, Kornblum, Geschwind: PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 (PubMed)
    Show all 2 references for ABIN668031

  2. Human PBK Protein expressed in Baculovirus infected Insect Cells - ABIN2003313 : Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN2003313

More Proteins for PDZ Binding Kinase (PBK) Interaction Partners

Human PDZ Binding Kinase (PBK) interaction partners

  1. Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.

  2. PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

  3. A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.

  4. findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC

  5. TOPK silencing sensitizes EGFR (show EGFR Proteins)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.

  6. Study shows that BUB1beta (show BUB1B Proteins) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.

  7. Overexpression of Nrf2 (show GABPA Proteins) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Proteins) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Proteins) production and apoptosis.

  8. The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.

  9. TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer

  10. Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP (show ZNF167 Proteins) linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 (show CDK1 Proteins) and linker phosphorylation in mitosis.

Mouse (Murine) PDZ Binding Kinase (PBK) interaction partners

  1. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (show AKT1 Proteins) signaling pathway

  2. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Proteins) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Proteins) signaling pathway.

  3. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  4. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Protein Profile

Protein Summary

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene names and symbols associated with PDZ Binding Kinase Proteins (PBK)

  • PDZ binding kinase (PBK)
  • PDZ binding kinase (pbk)
  • PDZ binding kinase (LOC100341076)
  • PDZ binding kinase (Pbk)
  • 2810434B10Rik protein
  • AW538537 protein
  • CT84 protein
  • D14Ertd732e protein
  • Nori-3 protein
  • PBK protein
  • SPK protein
  • TOPK protein
  • zgc:92050 protein

Protein level used designations for PDZ Binding Kinase Proteins (PBK)

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPECIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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