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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Antibodies (138) and PDZ Binding Kinase Kits (6) and many more products for this protein.
Showing 10 out of 12 products:
Human PBK Protein expressed in Escherichia coli (E. coli) - ABIN668031
Dougherty, Garcia, Nakano, Livingstone, Norris, Polakiewicz, Wexler, Sofroniew, Kornblum, Geschwind: PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Show all 2 references for ABIN668031
Human PBK Protein expressed in Baculovirus infected Insect Cells - ABIN2003313
Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000
Show all 2 references for ABIN2003313
Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.
PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.
A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.
findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC
TOPK silencing sensitizes EGFR (show EGFR Proteins)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.
Study shows that BUB1beta (show BUB1B Proteins) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Overexpression of Nrf2 (show GABPA Proteins) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Proteins) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Proteins) production and apoptosis.
The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.
TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer
Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP (show ZNF167 Proteins) linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 (show CDK1 Proteins) and linker phosphorylation in mitosis.
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (show AKT1 Proteins) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Proteins) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Proteins) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog