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PDZK1 encodes a PDZ domain-containing scaffolding protein. Additionally we are shipping PDZK1 Proteins (6) and PDZK1 Kits (4) and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal PDZK1 Primary Antibody for EIA, IHC (p) - ABIN954079
LaLonde, Garbett, Bretscher: A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. in Molecular biology of the cell 2010
Show all 5 references for ABIN954079
Human Monoclonal PDZK1 Primary Antibody for IHC (p) - ABIN2476097
Walker, MacLeod, Williams, Cameron, Smyth, Langdon: Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. in Gynecologic oncology 2007
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (show SLC9A3 Antibodies) dysfunction observed in the inflamed intestine.
PARP (show COL11A2 Antibodies) regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (show IGF1R Antibodies)/PDZK1 axis.
PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 (show MAPK1/3 Antibodies) phosphorylation.
Described is a structure of D-AKAP2 (show AKAP10 Antibodies) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta (show SUCLA2 Antibodies)-strand to PDZK1.
PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.
Correlation between PDZK1, Cdc37 (show CDC37 Antibodies), Akt (show AKT1 Antibodies) and breast cancer malignancy: the role of PDZK1 in cell growth through Akt (show AKT1 Antibodies) stabilization by increasing and interacting with Cdc37 (show CDC37 Antibodies)
IRF3 (show IRF3 Antibodies) activation by innate antiviral signaling represses TGF-beta (show TGFB1 Antibodies)-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naive CD4 (show CD4 Antibodies)(+) lymphocytes.
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
These results clarify the relationship between ER-alpha (show ESR1 Antibodies) and PDZK1, propose a direct relationship between PDZK1 and IGF1R (show IGF1R Antibodies), and identify a novel oncogenic activity for PDZK1 in breast cancer.
Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN (show ANLN Antibodies)); PDZ-Binding Kinase (PBK (show PBK Antibodies)); and, PDZ-Domain Containing 1 (PDZK1).
PDZK1 has novel SR-BI (show SCARB1 Antibodies)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (show BCR Antibodies)
Data show that interaction of the inducible nitric oxide synthase (iNOS (show NOS2 Antibodies)) C-terminus with the PDZ (show INADL Antibodies) domains of EBP50 (show SLC9A3R1 Antibodies) protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
PDZK1 regulates intracellular trafficking of Oatp1a1 (show Slco1a1 Antibodies).
PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (show SLC9A3 Antibodies).
SR-BI (show SCARB1 Antibodies) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (show SCARB1 Antibodies).
the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (show SCARB1 Antibodies).
The impairment of the absorptive function of the inflamed colon in the IL-10 (show IL10 Antibodies)(-/-) mouse, in spite of unaltered NHE3 (show SLC9A3 Antibodies) expression and localization, is accompanied by the downregulation of the NHE3 (show SLC9A3 Antibodies)-regulatory PDZ (show INADL Antibodies) adaptors NHERF2 (show SLC9A3R2 Antibodies) and PDZK1.
PDZK1 plays a pivotal role in the apical localization of BCRP (show ABCG2 Antibodies).
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ domain containing 1
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like
, CFTR-associated protein of 70 kDa
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
, PDZ-containing kidney protein 1
, na/Pi cotransporter C-terminal-associated protein 1
, sodium-hydrogen exchanger regulatory factor 3
, Na(+)/H(+) exchanger regulatory factor 3
, PDZ domain-containing protein 1
, PDZK1-like protein
, C-terminal linking and modulating protein
, C-terminal-linking and modulating protein
, dietary Pi-regulated RNA-1