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Protease which may deconjugate SUMO from some substrate proteins (By similarity). Additionally we are shipping PPPDE Peptidase Domain Containing 1 Antibodies (30) and many more products for this protein.
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The PPPDE1 could mediate the ubiquitin chain editing of RPS7 (show RPS7 Proteins), deubiquitinating Lys (show LYZ Proteins) 48-linked ubiquitination, and finally stabilize RPS7 (show RPS7 Proteins) proteins.
DESI2 (show PPPDE2 Proteins) may influence the AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signal in pancreatic cancer.
findings suggest a novel mechanism by which elevated PNAS-4 first causes DNA-dependent protein kinase (show CDK7 Proteins)-mediated Chk1 (show CHEK1 Proteins)/2 activation and then results in inhibition of the Cdc25A (show CDC25A Proteins)-CDK2 (show CDK2 Proteins)-cyclin E (show CCNE1 Proteins)/A pathway
hPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A (show CDC25A Proteins)-Cdk2 (show CDK2 Proteins)-Cyclin E (show CCNE1 Proteins)/Cyclin A (show CCNA2 Proteins) axis and mitochondrial dysfunction-mediated caspase (show CASP3 Proteins)-dependent and -independent apoptotic pathways.
PNAS-4 is not a p53 (show TP53 Proteins) target, but overexpression of PNAS-4 is correlated to p53 (show TP53 Proteins) inactivity in colorectal cancer.
overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells.
expression regulation and biological functions of PPPDE1 in development and carcinogenesis.
PNAS4 was not involved in mice brain development and apoptosis.
overexpression of mouse PNAS4 significantly suppressed Lewis lung carcinoma growth and prolonged survival time through induction of tumor cell apoptosis
PNAS-4 gene maps to pig chromosome 10, q11-16, and is upregulated after weaning. Homozygous pigs have a higher fat content.
Protease which may deconjugate SUMO from some substrate proteins (By similarity).
PPPDE peptidase domain-containing protein 1
, UPF0326 protein FAM152A
, family with sequence similarity 152, member A
, PPPDE peptidase domain containing 1
, desumoylating isopeptidase 1