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The protein encoded by PRPF4 is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. Additionally we are shipping PRP4 Pre-MRNA Processing Factor 4 Homolog (Yeast) Proteins (5) and many more products for this protein.
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Human Polyclonal PRPF4 Primary Antibody for IF, WB - ABIN522584
Tanackovic, Ransijn, Thibault, Abou Elela, Klinck, Berson, Chabot, Rivolta: PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. in Human molecular genetics 2011
Show all 2 Pubmed References
The p.R192H variant of PRPF4 represents a functional null allele which compromises the function of the tri (show VANGL2 Antibodies)-snRNP (show LSM2 Antibodies), reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina.
PRPF4 missense mutations is associated with autosomal dominant retinitis pigmentosa.
the requirement of enzymatic activity of PRP4 (show PRPF4B Antibodies) in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches
interaction between Hprp3p (show PRPF3 Antibodies) and Hprp4p
PRP4 (show PRPF4B Antibodies) is a spindle assembly checkpoint protein required for MPS1 (show IDUA Antibodies), MAD1 (show MXD1 Antibodies), and MAD2 (show MAD2L1 Antibodies) localization to the kinetochores.
PRP-4 (show PRPF4B Antibodies) belongs to the serine/threonine protein kinase (show PRKACG Antibodies) family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1 (show CDK11B Antibodies)
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene.
U4/U6 small nuclear ribonucleoprotein Prp4
, PRP4 pre-mRNA processing factor 4 homolog (yeast)
, WD40 repeat-containing protein
, pre-mRNA processing factor 4
, U4/U6 small nuclear ribonucleoprotein Prp4-like
, PRP4 homolog
, PRP4/STK/WD splicing factor
, U4/U6 snRNP 60 kDa protein
, WD splicing factor Prp4