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PAX8 encodes a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX8 Antibodies (147) and PAX8 Kits (1) and many more products for this protein.
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Human PAX8 Protein expressed in Escherichia coli (E. coli) - ABIN2006212
Poleev, Wendler, Fickenscher, Zannini, Yaginuma, Abbott, Plachov: Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. in European journal of biochemistry / FEBS 1995
High Levels of mRNA of both PAX8 are associated with benign than in malignant thyroid lesions.
results indicate that presence of PAX8 immunoreactivity in an undifferentiated brain tumor lacking gliofibrillary acidic protein expression should prompt consideration of a metastatic tumor
rete ovarii were positive for PAX-8, weakly positive for SF-1 (show NR5A1 Proteins), and negative for PAX-2 (show PAX2 Proteins) and GATA-3 (show GATA3 Proteins)
showing that the PAX8 mutation rate is very low in thyroid dysgenesis patients in China
a substantial minority of solitary fibrous tumors express nuclear PAX8 and PAX2 (show PAX2 Proteins)
PAX8 staining is useful for distinguishing between primary thyroid squamous cell carcinoma and invasion or metastasis from extrathyroidal squamous cell carcinoma.
PAX8 is expressed in the majority of benign, premalignant, and malignant endocervical glandular lesions.
PAX8 mutation rate among congenital hypothyroidism patients
the novel interplay between PAX8 and Neuropilin-2 (show NRP2 Proteins)
Heterozygous transition in exon 3 of PAX8 gene is associated with hyroid hypoplasia.
Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b (show HNF1B Proteins) and wnt (show WNT2 Proteins) pathway genes in the kidney field.
nephrogenic transcription factors (osr1 (show OSR1 Proteins), osr2, hnf1b (show HNF1B Proteins), lhx1 (show LHX1 Proteins), pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid
These results suggest that Pax8 maybe the downstream molecule of ALK3 (show BMPR1A Proteins), it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development.
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure
PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.
Pax8 is essential for function and survival of adult thyroid cells.
a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.
Inducible, Pax8-rtTA-based deletion of VHL (show VHL Proteins) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO Proteins) in liver and kidney without causing pathological changes.
study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell
a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene
these data identify Pax2 (show PAX2 Proteins) and Pax8 as critical regulators that specify the nephric lineage.
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Proteins), a necessary step for further otic development
evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1 (show FOXI1 Proteins)-Pax8 pathways
Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
paired box 8
, paired box gene 8
, paired box protein Pax-8
, paired domain gene 8
, Pax-8 protein
, Pax-8 DNA-binding transcription factor