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Paired Box 8 Proteins (PAX8)

PAX8 encodes a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX8 Antibodies (142) and PAX8 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAX8 7849 Q06710
PAX8 81819 P51974
PAX8 18510 Q00288
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Top PAX8 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,287.17
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,290.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,309.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$510.36
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

PAX8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus) ,

Mouse (Murine)

Top referenced PAX8 Proteins

  1. Human PAX8 Protein expressed in Escherichia coli (E. coli) - ABIN2006212 : Poleev, Wendler, Fickenscher, Zannini, Yaginuma, Abbott, Plachov: Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. in European journal of biochemistry / FEBS 1995 (PubMed)

More Proteins for Paired Box 8 (PAX8) Interaction Partners

Human Paired Box 8 (PAX8) interaction partners

  1. a substantial minority of solitary fibrous tumors express nuclear PAX8 and PAX2 (show PAX2 Proteins)

  2. PAX8 staining is useful for distinguishing between primary thyroid squamous cell carcinoma and invasion or metastasis from extrathyroidal squamous cell carcinoma.

  3. PAX8 is expressed in the majority of benign, premalignant, and malignant endocervical glandular lesions.

  4. PAX8 mutation rate among congenital hypothyroidism patients

  5. the novel interplay between PAX8 and Neuropilin-2 (show NRP2 Proteins)

  6. Heterozygous transition in exon 3 of PAX8 gene is associated with hyroid hypoplasia.

  7. miR (show MLXIP Proteins)-146b-3p binds to the 3'-untranslated region of PAX8 and sodium/iodide symporter. miR (show MLXIP Proteins)-146b and PAX8 regulate each other and share common target genes.

  8. we examined PAX8-PPARgamma (show PPARG Proteins) rearrangement in 24 follicular thyroid carcinoma samples from Japanese patients. The fusion gene was detected in only one of 24 follicular thyroid carcinomas (4%).

  9. PAX8 protein expression was associated with germinal layers in forebrain and hindbrain development...and PAX8 expression is linked to better prognosis in medulloblastomas

  10. PAX2 (show PAX2 Proteins) and PAX8 are useful biomarker in the differential diagnosis of ovarian serous and mucinous tumors

Xenopus laevis Paired Box 8 (PAX8) interaction partners

  1. Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b (show HNF1B Proteins) and wnt (show WNT2 Proteins) pathway genes in the kidney field.

  2. nephrogenic transcription factors (osr1 (show OSR1 Proteins), osr2, hnf1b (show HNF1B Proteins), lhx1 (show LHX1 Proteins), pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid

Mouse (Murine) Paired Box 8 (PAX8) interaction partners

  1. Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

  2. PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.

  3. Pax8 is essential for function and survival of adult thyroid cells.

  4. a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.

  5. The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.

  6. Inducible, Pax8-rtTA-based deletion of VHL (show VHL Proteins) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO Proteins) in liver and kidney without causing pathological changes.

  7. study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell

  8. a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene

  9. these data identify Pax2 (show PAX2 Proteins) and Pax8 as critical regulators that specify the nephric lineage.

  10. The Box protein Pax-8 gene is an important and cardiac-specific ALK3 downstream gene in the BMP signaling pathway during inter-ventricular septum development.

Zebrafish Paired Box 8 (PAX8) interaction partners

  1. Pax2a and Pax8 regulate cell differentiation during sensory placode formation

  2. pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Proteins), a necessary step for further otic development

  3. evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1 (show FOXI1 Proteins)-Pax8 pathways

  4. Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation

  5. pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate

PAX8 Protein Profile

Protein Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with Paired Box 8 Proteins (PAX8)

  • paired box 8 (PAX8)
  • paired box 8 (pax8)
  • paired box 8 (Pax8)
  • paired box gene 8 (Pax8)
  • paired box gene 8 (pax8)
  • Pax-8 protein
  • PAX8 protein
  • XPax-8 protein
  • XPax8 protein

Protein level used designations for Paired Box 8 Proteins (PAX8)

paired box 8 , paired box gene 8 , paired box protein Pax-8 , paired domain gene 8 , Pax-8 protein , Pax-8 DNA-binding transcription factor , XPax-8

GENE ID SPECIES
701906 Macaca mulatta
780226 Xenopus (Silurana) tropicalis
100189903 Pongo abelii
7849 Homo sapiens
81819 Rattus norvegicus
403927 Canis lupus familiaris
534661 Bos taurus
398132 Xenopus laevis
18510 Mus musculus
60637 Danio rerio
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