anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Antibodies

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Kits (18) and PARK2 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top anti-PARK2 Antibodies at antibodies-online.com

Showing 10 out of 180 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-Park2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Mouse Liver WB Suggested Anti-Park2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Mouse Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (ABIN390365) in NCI-H460 cell line lysates (35 µg/lane). PARK2 (Parkin)(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB The anti-Parkin C-term Pab (ABIN390366) is used in Western blot to detect Parkin in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of Parkin staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of Parkin expression in HepG2 (A), SHSY5Y (B), SW480 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB ABIN251684 (0.1?g/ml) staining of Human Brain (frontal cortex) lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: Parkin Antibody [ABIN2516848] - Western Blot analysis of Parkin in human brain (frontal cortex) lysate using this antibody at 0.1 ug/ml. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Western Blot: Parkin Antibody [ABIN4077841] - Extracts from Jurkat cells. Immunohistochemistry-Paraffin: Parkin Antibody [ABIN4077841] - Paraffin-embedded human brain tissue. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Anti- Parkin Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti- Parkin Picoband antibody, IHC(P) IHC(P): Mouse Brain Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using Parkin (Phospho-Ser131) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell (antibody concentration 10 µg/mL). PARK2 monoclonal antibody (M01), clone 1H4 Western Blot analysis of PARK2 expression in Jurkat. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Parkin protein/PARK2 Polyclonal Antibody, Unconjugated (ABIN735578) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat testis labeled with Anti-Parkin protein/PARK2 Polyclonal Antibody, Unconjugated (ABIN735578) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details

PARK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PARK2 Antibodies

  1. Human Polyclonal PARK2 Primary Antibody for ICC, IF - ABIN407784 : Eid, Ito, Otsuki: Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases. in Frontiers in pharmacology 2016 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal PARK2 Primary Antibody for ELISA, WB - ABIN251684 : La Cognata, Iemmolo, DAgata, Scuderi, Drago, Zappia, Cavallaro: Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. in Current genomics 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PARK2 Primary Antibody for IHC (p), IP - ABIN269703 : Scuderi, La Cognata, Drago, Cavallaro, DAgata: Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. in BioMed research international 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal PARK2 Primary Antibody for IF, ELISA - ABIN562106 : Brody, Taylor, Wilson, Delatycki, Lockhart: Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain. in Brain research 2008 (PubMed)

  5. Human Polyclonal PARK2 Primary Antibody for IF (p), IHC (p) - ABIN735578 : Li, Zhang, Wang, Liu, Yang, Liu, Lu: Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)

  6. Human Monoclonal PARK2 Primary Antibody for IF, WB - ABIN2476069 : Ostby: [Fredrik Nightingale fellows]. in Journalen sykepleien 1990 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PARK2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Maintenance of tissue homeostasis upon reduction of Pink1 (show PINK1 Antibodies) or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  2. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (show PINK1 Antibodies) and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  3. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  4. autophosphorylation of PINK1 (show PINK1 Antibodies) is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  5. Our data indicate that PINK1 (show PINK1 Antibodies) and Parkin play an important role in FUS (show FUS Antibodies)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS Antibodies) proteinopathy and PINK1 (show PINK1 Antibodies)/Parkin genes, providing new insights into the pathogenesis of FUS (show FUS Antibodies) proteinopathy.

  6. Clu (show CLU Antibodies) is upstream of and binds to VCP (show vcp Antibodies) in vivo and promotes VCP (show vcp Antibodies)-dependent Marf (show MFN2 Antibodies) degradation in vitro Marf (show MFN2 Antibodies) accumulates in whole muscle lysates of clu (show CLU Antibodies)-deficient flies and is destabilized upon Clu (show CLU Antibodies) overexpression. Thus, Clu (show CLU Antibodies) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (show vcp Antibodies) for Marf (show MFN2 Antibodies) degradation to promote damaged mitochondrial clearance.

  7. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 (show PINK1 Antibodies) phenotypes in Drosophila

  8. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  9. We demonstrate here that vps35 (show vps35 Antibodies) genetically interacts with parkin

  10. Clu (show CLU Antibodies) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1 (show PINK1 Antibodies)-Park pathway of mitochondrial quality control.

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Melatonin, added together with MPTP (show PTPN2 Antibodies) or added once MPTP (show PTPN2 Antibodies) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1 (show PINK1 Antibodies)/DJ-1 (show PARK7 Antibodies)/MUL1 loop and also the normal motor activity of the embryos.

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB Antibodies)/PI3K/AKT (show AKT1 Antibodies) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  2. Mfn2 (show MFN2 Antibodies) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 Antibodies)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  3. Our results provide a molecular explanation for the contribution of Drp1 (show CRMP1 Antibodies) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin pathway may be a novel therapeutic target to treat PD

  4. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  5. These studies suggest that changes in intestinal lipid absorption may play a primary role in protection from nutritional stress in Park2 KO mice by preventing HFD-induced weight gain and highlight the need for tissue-specific models to address the role of PARK2 during metabolic stress.

  6. Parkin negatively regulates the number and connectivity of mitochondria via a Drp1 (show CRMP1 Antibodies)-independent mechanism.

  7. Parkin-overexpressing cells also showed reductions in apoptotic BAX (show BAX Antibodies) translocation to the mitochondria and cytochrome c (show CYCS Antibodies) release to the cytosol

  8. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 Antibodies).

  9. The identification of PINK1 (show PINK1 Antibodies) and Parkin as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  10. p62 (show GTF2H1 Antibodies) are subjected to parkin mediated proteasomal degradation

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. these results unveil a novel functional coupling between Parkin and the CaV2.2 (show CACNA1B Antibodies) channels.

  2. These results demonstrate the feasibility of using UbFluor for quantitative studies of the biochemistry of RBR E3s and for high-throughput screening of small-molecule activators or inhibitors of PARKIN and other RBR E3 ligases.

  3. data suggest that ROS (show ROS1 Antibodies) may act as a trigger for the induction of Parkin/PINK1 (show PINK1 Antibodies)-dependent mitophagy.

  4. The proportions of some phospholipids and glycosphingolipids were altered in the lipid profiles of parkin-mutant skin fibroblasts obtained from Parkinson disease patients.

  5. Adipogenic process can be dissected into 3 stages according to the participation of PARL (show PARL Antibodies)-PINK1 (show PINK1 Antibodies)-Parkin system. Findings reveal the sequential adipogenic events directed by PARL (show PARL Antibodies)-PINK1 (show PINK1 Antibodies)-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  6. These results highlight the combined effects of Parkin and PGC-1alpha (show PPARGC1A Antibodies) in the maintenance of mitochondrial homeostasis in dopaminergic neurons. These two factors synergistically control the quality and function of mitochondria, which is important for the survival of neurons in Parkinson's disease.

  7. Data suggest that inactivation of cytosolic parkin in dopaminergic neurons of the substantia nigra contributes to neurodegeneration in sporadic Parkinson disease. [REVIEW]

  8. we identified a genome-wide significant association involving measures of midface height at 6q26 within an intron of PARK2

  9. PARK2 inactivation connects energy and oxidative stress to Akt (show AKT1 Antibodies) activation via redox-mediated inactivation of PTEN (show PTEN Antibodies) by S-nitrosylation to support cell survival under conditions of energy deprivation.

  10. These results suggest that degradation of endogenous APE1 (show APEX1 Antibodies) by Parkin occur when cells are stressed to activate Parkin, and imply a role of Parkin in maintaining the quality of APE1 (show APEX1 Antibodies), and loss of Parkin may contribute to elevated APE1 (show APEX1 Antibodies) levels in glioblastoma.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Antigen Profile

Protein Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) antibody
  • parkin (CpipJ_CPIJ014867) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2) antibody
  • AR-JP antibody
  • CG10523 antibody
  • Dmel\\CG10523 antibody
  • Dpark antibody
  • dpk antibody
  • LOC100150461 antibody
  • LPRS2 antibody
  • Park antibody
  • PDJ antibody
  • pdr-1 antibody
  • Prkn antibody
  • SD01679 antibody
  • si:ch211-123f21.1 antibody
  • zgc:112390 antibody

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
Selected quality suppliers for anti-PARK2 (PARK2) Antibodies
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