Peptidyl Arginine Deiminase, Type IV Proteins (PADI4)

PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. Additionally we are shipping PADI4 Antibodies (109) and PADI4 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PADI4 23569 Q9UM07
PADI4 18602 Q9Z183
PADI4 29512 O88807
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Top PADI4 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag,GST tag 10 μg Log in to see 20 to 21 Days
$277.20
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human His tag SDS-PAGE 50 μg Log in to see 20 to 21 Days
$547.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,934.33
Details
Insect Cells Mouse GST tag   100 μg Log in to see 25 to 30 Days
$799.71
Details

PADI4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for Peptidyl Arginine Deiminase, Type IV (PADI4) Interaction Partners

Human Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 epitopes in rheumatoid arthritis.

  2. No associations were found between clinical subtypes of JIA and PADI4 allele frequency. rs2240337 in the PADI4 gene was significantly associated with anti-cyclic citrullinated peptide antibody-positivity in juvenile idiopathic arthritis.

  3. The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated in a meta-analysis. The overall analysis indicated a significant association between the PADI4-104C/T polymorphism and RA risk in the Chinese population (T vs C: OR = 1.45, 95%CI = 1.18-1.78; TT vs CC: OR = 1.49, 95%CI = 1.24-1.80; TT vs CC+CT: OR = 1.28, 95%CI = 1.08-1.51; TT+CT vs CC: OR = 1.75, 95%CI = 1.30-2.37).

  4. Overexpression of PAD4 constrains the activity of EMT (show ITK Proteins) via suppressing Elk1 (show ELK1 Proteins) expression.

  5. Our study also demonstrated that PADI4 contributes to tumor metastasis by regulating the gene expression of insulin-like growth factor 1 (IGF1 (show IGF1 Proteins)) and WAS/WASL-interacting protein family member 1 (WIPF1 (show WIPF1 Proteins)).

  6. PAD4 levels were significantly higher in patients with rheumatoid arthritis than in patients with systemic lupus erythematosis or healthy controls. Anti-PAD4 antibodies were detected in 30% of patients with rheumatoid arthritis, but not in patients with SLE, systemic sclerosis or controls.

  7. This meta-analysis showed that the PADI4 -94G/A variants may influence RA risk in the Chinese population.

  8. The results highlight an association between PAD4 and DNA hypermethylation in acute promyelocytic leukemia (show PML Proteins) and demonstrate that targeting PAD4 or regulating its downstream effectors may be a promising strategy to control differentiation in the clinic.

  9. We identified the presence of PADI3 (show PADI3 Proteins) mRNA expression in synovial tissue and PADI2 (show PADI2 Proteins) and PADI4 mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  10. Polymorphism in exon-4 of PADI4 gene showed significant association with rheumatoid arthritis (RA)and polymorphism in exon-3 exhibited moderate association with RA.

Mouse (Murine) Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.

  2. PADI4 exacerbates arthritis with diverse immunological modifications.

  3. Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.

  4. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression

  5. PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc (show MYC Proteins) expression.

  6. PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

  7. PAD4 is dispensable in this effector phase model of arthritis

  8. analysis of regulation of histone modification and chromatin structure by the p53 (show TP53 Proteins)-PADI4 pathway

  9. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

PADI4 Protein Profile

Protein Summary

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Gene names and symbols associated with PADI4

  • peptidyl arginine deiminase, type IV (PADI4)
  • peptidyl arginine deiminase, type IV (Padi4)
  • PAD protein
  • Pad4 protein
  • PADI5 protein
  • Pdi4 protein
  • PDI5 protein

Protein level used designations for PADI4

peptidyl arginine deiminase, type IV , protein-arginine deiminase type-4-like , HL-60 PAD , PADI-H protein , peptidyl arginine deiminase, type V , protein-arginine deiminase type IV , protein-arginine deiminase type-4 , PAD type IV , peptidylarginine deiminase IV , PAD-R4 , peptidyl arginine deiminase, type 4 , peptidylarginine deiminase type alpha

GENE ID SPECIES
100026011 Monodelphis domestica
100049826 Equus caballus
100415489 Callithrix jacchus
100471129 Ailuropoda melanoleuca
100592291 Nomascus leucogenys
23569 Homo sapiens
18602 Mus musculus
456530 Pan troglodytes
29512 Rattus norvegicus
606921 Canis lupus familiaris
508161 Bos taurus
100524749 Sus scrofa
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