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Peptidylprolyl Isomerase A (Cyclophilin A) Proteins (PPIA)

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Additionally we are shipping PPIA Antibodies (155) and PPIA Kits (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPIA 268373 P17742
PPIA 5478 P62937
PPIA 25518 P10111
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Top PPIA Proteins at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST serum (WB) and peptide fingerprinting by MALDI-TOF-TOF mass spectrometry 50 μg Log in to see 5 to 7 Days
$254.10
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) (AA 2-165), (full length) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$250.80
Details

PPIA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,
Rat (Rattus) ,

Top referenced PPIA Proteins

  1. Human PPIA Protein expressed in Wheat germ - ABIN1315865 : He, Wang, Srinivasan, Xu, Padilla, Li, Wang, Liu, Gou, Shen, Xing, Lin: A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. in Oncogene 2014 (PubMed)
    Show all 2 references for ABIN1315865

  2. Human PPIA Protein expressed in Escherichia coli (E. coli) - ABIN666698 : Holzman, Egan, Edalji, Simmer, Helfrich, Taylor, Burres: Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin. in The Journal of biological chemistry 1991 (PubMed)
    Show all 2 references for ABIN666698

More Proteins for Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Interaction Partners

Xenopus laevis Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

Mouse (Murine) Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt (show AKT1 Proteins)-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  2. CypA provided stability for NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) and promoted NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB (show NFKB1 Proteins) activity.

  3. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.

  4. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice.

  5. CD137 (show TNFRSF9 Proteins)-CD137L (show TNFSF9 Proteins) interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

  6. Reactive oxygen species-dependent CypA secretion by endothelial cells is an important signaling mechanism through which endothelial cell reactive oxygen species regulate susceptibility of structural components of the aortic wall to aortic dissection.

  7. CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae.

  8. CYPA was identified as a novel host restriction factor that confered protection against rotavirus infection.

  9. CyPA expression increases and may modulate inflammatory cell adhesion and interleukin-6 (show IL6 Proteins) expression inducing vascular smooth muscle cell migration and inflammatory cell extravasation in a time-dependent manner

  10. How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced glutathione peroxidase 1 (show GPX1 Proteins) (i.e., oxidative stress) promotes secretion of CypA which mediates paracrine inflammation of vasculature.

Human Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. the states of phosphorylation of Cyp (show PPIG Proteins) A by Akt (show AKT1 Proteins) can influence the progress of the cell cycle in multiple myeloma.

  2. review of PPIA polymorphisms and what is known about their impact on the replication cycle and course of disease for different viral infections

  3. The present knowledge on the role of cyclophilin A during coronavirus replication is summarized (Review)

  4. CsA (show ERCC8 Proteins) and FK506 might interfere with selected effector T cell functions via a CrkII (show CRK Proteins)-, but not CrkI-dependent mechanisms.

  5. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt (show AKT1 Proteins)-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  6. Overexpression of CypA/WT protected the cells against cisplatin or H2O2-induced oxidative damage, however, the CypA/P16S mutant had no effect. These findings suggested that CypA exhibits a protective antioxidant effect

  7. The poor prognosis of esophageal cancer patients was associated with high expression of CypA.

  8. These results indicate a special function mode for CypA of playing more important roles in the early stage of gastric tumorigenesis.

  9. Cyclophilin A regulates HIV-1 replication kinetics and infectivity, modulates sensitivity to host restriction factors, and cooperates in the transit of the pre-integration complex into the nucleus of infected cells.

  10. The frequency of immunihistochemistry detected cyclophilin A protein expression was found to be equal in tumor of both histotypes.

PPIA Protein Profile

Protein Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Gene names and symbols associated with PPIA

  • peptidylprolyl isomerase A (cyclophilin A) (PPIA)
  • peptidylprolyl isomerase Aa (cyclophilin A) (ppiaa)
  • peptidylprolyl isomerase A (cyclophilin A) (ppia)
  • cyclophilin A (CypA)
  • cyclophilin A (Cypa)
  • cyclophilin A (CNB01230)
  • cyclophilin A (CNB01290)
  • cyclophilin A (Tc00.1047053506925.300)
  • cyclophilin A (Tb11.03.0250)
  • cyclophilin a (LmjF25.0910)
  • olfactory receptor, family 4, subfamily L, member 1-like (LOC788146)
  • peptidyl-prolyl cis-trans isomerase A-like (LOC100773511)
  • peptidylprolyl isomerase A (Ppia)
  • peptidylprolyl isomerase A (cyclophilin A) (Ppia)
  • 2700098C05 protein
  • Cphn protein
  • CYCA protein
  • CyP-18 protein
  • CyP-A protein
  • Cyp1 protein
  • cypA protein
  • CYPH protein
  • fa93g09 protein
  • MGC75715 protein
  • MT-ND1 protein
  • MTND1 protein
  • NADH1 protein
  • ND1 protein
  • PPIA protein
  • PPIA-2 protein
  • wu:fa93g09 protein
  • wu:fb05e11 protein
  • wu:fb13h02 protein
  • wu:fb15a05 protein

Protein level used designations for PPIA

peptidyl-prolyl cis-trans isomerase A , 2-peptidylprolyl isomerase A , peptidylprolyl isomerase A (cyclophilin A) , cyclophilin A , immunophilin , PPIase A , cyclosporin A-binding protein , rotamase A , cyclophilin-like , cyclophilin a , Cyclophilin A , Cyclosporin A-binding protein , Rotamase A , Peptidyl-prolyl cis-trans isomerase A , SP18 , T cell cyclophilin , cyclophilin , p1B15 , p31 , cyclophilin T , cyclophilin T-cell , cyclophilin 18 , NADH dehydrogenase subunit 1 , NADH-ubiquinone oxidoreductase chain 1

GENE ID SPECIES
100173012 Pongo abelii
336612 Danio rerio
394470 Xenopus (Silurana) tropicalis
398630 Xenopus laevis
403581 Canis lupus familiaris
463386 Pan troglodytes
606861 Canis lupus familiaris
692737 Bombyx mori
786614 Bos taurus
3255869 Cryptococcus neoformans var. neoformans JEC21
3255972 Cryptococcus neoformans var. neoformans JEC21
3554513 Trypanosoma cruzi strain CL Brener
3664945 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5652501 Leishmania major strain Friedlin
100594480 Nomascus leucogenys
788146 Bos taurus
100773511 Cricetulus griseus
268373 Mus musculus
5478 Homo sapiens
608151 Canis lupus familiaris
25518 Rattus norvegicus
397637 Sus scrofa
281418 Bos taurus
100008724 Oryctolagus cuniculus
493966 Felis catus
776282 Gallus gallus
443258 Ovis aries
574102 Macaca mulatta
473924 Pan troglodytes
100973085 Pan paniscus
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