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The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity). Additionally we are shipping Peptidyl-tRNA Hydrolase 2 Proteins (13) and many more products for this protein.
Showing 10 out of 80 products:
Human Polyclonal PTRH2 Primary Antibody for WB - ABIN1881706
Fan, Jiang, Suo, Liu, Xu, Ji, Zhang, Yang: Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells. in International journal of oncology 2009
Show all 5 references for ABIN1881706
Human Polyclonal PTRH2 Primary Antibody for EIA, IHC (p) - ABIN499473
Martin, Vuori: Regulation of Bcl-2 proteins during anoikis and amorphosis. in Biochimica et biophysica acta 2004
Show all 3 references for ABIN499473
Human Polyclonal PTRH2 Primary Antibody for ICC, IF - ABIN4348629
Karmali, Brunquell, Tram, Ireland, Ruoslahti, Biliran: Metastasis of tumor cells is enhanced by downregulation of Bit1. in PLoS ONE 2011
Show all 3 references for ABIN4348629
Human Polyclonal PTRH2 Primary Antibody for IHC (p), WB - ABIN650622
Jan, Matter, Pai, Chen, Pilch, Komatsu, Ong, Fukuda, Ruoslahti: A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. in Cell 2004
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Bit1 may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK (show PTK2 Antibodies)-paxillin (show PXN Antibodies) pathway.
these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer.
Reduction of the Bit1 level in cytosol, regulated by E2 binding to ESR1 (show ESR1 Antibodies), was mainly mediated through PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathways.
Bit1 plays pivotal roles in the development and progression of ESCC, and its biological functions in ESCC may be closely associated with AIF (show AIFM1 Antibodies) and Bcl-2 (show BCL2 Antibodies) levels.
TLE1 (show TLE1 Antibodies) inhibits the Bit1 anoikis pathway by reducing the formation of the proapoptotic Bit1-AES (show AES Antibodies) complex in part through sequestration of AES (show AES Antibodies) in the nucleus.
Bit1 may be a useful pathological marker and a prognostic marker for serous papillary adenocarcinomas outcome.
Data indicate that the cell death domain (CDD) to the N-terminal 62 amino acids of Bit1 was more potent in killing cells than the full-length Bit1 protein when equivalent amounts of cDNA were transfected.
downregulation of Bit1 conferred cancer cells with enhanced anoikis resistance, adhesive and migratory properties in vitro
Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
Results identify Bit1, a mitochondrial protein (show COX6B2 Antibodies) released into the cytoplasm during apoptosis that forms a complex with AES (show AES Antibodies), a small Groucho/transducin (show GNAT1 Antibodies)-like enhancer of split (TLE) protein
These results support an unanticipated yet essential role for Bit-1 in controlling myogenesis through regulation of Bcl-2 (show BCL2 Antibodies).
downregulation of Bit1 specifically potentiated tumor metastasis in vivo
These studies establish the physiological significance of Bit1 activity and begin to delineate a Bit1 signaling pathway that acts through Erk (show EPHB2 Antibodies) regulation.
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity).
peptidyl-tRNA hydrolase 2
, PTH 2
, bcl-2 inhibitor of transcription 1
, peptidyl-tRNA hydrolase 2, mitochondrial
, Bcl-2 inhibitor of transcription