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Phosphatidylinositol Binding clathrin Assembly Protein Proteins (PICALM)

PICALM encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. Additionally we are shipping Phosphatidylinositol Binding clathrin Assembly Protein Antibodies (78) and Phosphatidylinositol Binding clathrin Assembly Protein Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PICALM 289668 Q68FS4
PICALM 8301 Q13492
PICALM 233489 Q7M6Y3
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Top Phosphatidylinositol Binding clathrin Assembly Protein Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 4 pack Log in to see 10 to 12 Days
$86.96
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,850.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

PICALM Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

Top referenced Phosphatidylinositol Binding clathrin Assembly Protein Proteins

  1. Human PICALM Protein expressed in Escherichia coli (E. coli) - ABIN2667547 : Khalil: TGF-beta: from latent to active. in Microbes and infection / Institut Pasteur 2000 (PubMed)
    Show all 4 references for ABIN2667547

  2. Human PICALM Protein expressed in Wheat germ - ABIN1315001 : Baig, Joseph, Tayler, Abraham, Owen, Williams, Kehoe, Love: Distribution and expression of picalm in Alzheimer disease. in Journal of neuropathology and experimental neurology 2010 (PubMed)

More Proteins for Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) Interaction Partners

Fruit Fly (Drosophila melanogaster) Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. results reveal a new mode by which AP180 couples protein retrieval to CME of SVs (show FGFR2 Proteins)

  2. clathrin adapter protein (show GRB10 Proteins)

Human Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. PICALM and CLU (show CLU Proteins) risk genotypes exert differential impacts on the hippocampal resting-state functional connectivity in healthy young subjects.

  2. PICALM has a role in modulating autophagy activity and tau accumulation

  3. the rs541458 and rs3851179 of PICALM SNPs are not related to development of behavioral and psychological symptoms of dementia in Turkish population

  4. We detected a significant association of the MTHFR (show MTHFR Proteins) rs1801133 and PICALM rs3851179 polymorphisms with AD.

  5. PICALM SNP is significantly associated with late onset Alzheimer disease.

  6. CALM is a major factor in controlling endocytic clathrin-coated vesicle size and maturation and hence in determining the rates of endocytic cargo uptake.

  7. Data suggest a neural mechanism for APOE (show APOE Proteins)-PICALM interactions in patients with manifest Alzheimer's disease and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE (show APOE Proteins) epsilon4 carrier

  8. multiple PICALM isoforms are expressed in the human brain, that PICALM is robustly expressed in microvessels, and that expression of total PICALM is modestly correlated with the AD-associated SNP rs3851179.

  9. allelic expression has shown that compelling PICALM allelic expression imbalance was not observed in most brain RNA samples

  10. physical activity attenuated the effects of genetic risk (ie. the constellation of PICALM, BIN1 (show BIN1 Proteins), and CLU (show CLU Proteins) polymorphisms) on episodic memory

Mouse (Murine) Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. Confinement within the presynaptic bouton is mediated in part by synaptic vesicle protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins.

  2. the PICALM PIP2 binding domain is necessary for transferrin receptor endocytosis in erythroblasts and absolutely essential for erythroid development from mouse hematopoietic stem/progenitor cells in an erythroid culture system.

  3. During leukemogenesis, CALM-AF10 (show MLLT10 Proteins) plays critical roles in the cytoplasm.

  4. These data reveal that PICALM plays a critical role in iron homeostasis.

  5. PICALM, an adaptor protein involved in clathrin-mediated endocytosis, regulates APP (show APP Proteins) internalization and subsequent Abeta (show APP Proteins) generation. PICALM contributes to amyloid plaque load in brain likely via its effect on Abeta (show APP Proteins) metabolism.

  6. These results indicate that CALM is required for erythroid maturation and transferrin (show Tf Proteins) internalization in mice.

  7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  8. the Rarb (show RARB Proteins) region of Mmu14 and Stmn2 (show STMN2 Proteins), but not Cr1 (show TDGF1 Proteins) or Clu (show CLU Proteins) or Picalm have roles in prion (show PRNP Proteins) disease

  9. fit14R & fit15R are nonsense point mutations in the mouse PICALM gene. They are splice-donor alterations causing transcripts less abundant transcripts missing exons 4 & 17, respectively. The protein is truncated near the N or C termini, respectively.

Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) Protein Profile

Protein Summary

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PICALM

  • like-AP180 (lap)
  • leucine aminopeptidase 3 (Lap3)
  • phosphatidylinositol binding clathrin assembly protein (PICALM)
  • phosphatidylinositol binding clathrin assembly protein (Picalm)
  • AP180 protein
  • BcDNA:GM10787 protein
  • Calm protein
  • CG2520 protein
  • CLTH protein
  • dAP-3 protein
  • Dmel\\CG2520 protein
  • EP(3)3060 protein
  • EP3060 protein
  • fit-1 protein
  • fit1 protein
  • l(3)neo34 protein
  • Lap protein
  • LAP-3 protein
  • lap/AP180 protein
  • mKIAA4114 protein
  • PAP180 protein
  • sig protein

Protein level used designations for PICALM

CG2520-PA , CG2520-PC , CG2520-PD , CG2520-PE , CG2520-PF , CG2520-PG , CG2520-PH , CG2520-PI , CG2520-PJ , EP3060 , Like-AP180 , complementation group 12 , lap-PA , lap-PC , lap-PD , lap-PE , lap-PF , lap-PG , lap-PH , lap-PI , lap-PJ , like AP180 , saisoog , LAP , cytosol aminopeptidase , leucyl aminopeptidase , proline aminopeptidase , prolyl aminopeptidase , clathrin assembly lymphoid myeloid leukemia protein , phosphatidylinositol-binding clathrin assembly protein , clathrin assembly lymphoid myeloid leukemia , clathrin-assembly lymphoid leukemia protein , clathrin-assembly lymphoid myeloid leukemia protein , rCALM

GENE ID SPECIES
40863 Drosophila melanogaster
289668 Rattus norvegicus
8301 Homo sapiens
233489 Mus musculus
89816 Rattus norvegicus
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