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Phosphorylase, Glycogen, Muscle Proteins (PYGM)

PYGM encodes a muscle enzyme involved in glycogenolysis. Additionally we are shipping Phosphorylase, Glycogen, Muscle Antibodies (73) and Phosphorylase, Glycogen, Muscle Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PYGM 19309 Q9WUB3
PYGM 5837 P11217
Rat PYGM PYGM 24701  
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Top Phosphorylase, Glycogen, Muscle Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PYGM Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

More Proteins for Phosphorylase, Glycogen, Muscle (PYGM) Interaction Partners

Horse (Equine) Phosphorylase, Glycogen, Muscle (PYGM) interaction partners

  1. The horse PYGM gene was broadly expressed in all tissues tested with the highest expression observed in skeletal muscle. It contains fewer mobile elements than its human ortholog, resulting in an increase in the structural stability of the gene sequence.

Mouse (Murine) Phosphorylase, Glycogen, Muscle (PYGM) interaction partners

  1. Data suggest that the irreversible inhibition of glycogen (show GYS1 Proteins) phosphorylase (GP) could represent one of the mechanisms that contribute to mercury-dependent muscle toxicity.

  2. Data show that glycogen (show GYS1 Proteins) phosphorylase is irreversibly impaired by exposure to peroxynitrite, and suggest that the peroxynitrite-dependent inactivation of the enzyme could be due to the nitration of Tyr613 at the allosteric inhibitor site of the enzyme.

Rabbit Phosphorylase, Glycogen, Muscle (PYGM) interaction partners

  1. The formation of a complex between the denatured monomeric form of Phb (show PHB Proteins) and the dissociated forms of GroEL (show GroEL Proteins) is detected during heating at 46 degrees C.

  2. alpha-crystallin interacts with the intermediates of unfolding of the Phb (show PHB Proteins) molecule

Human Phosphorylase, Glycogen, Muscle (PYGM) interaction partners

  1. update of the reported mutations and polymorphisms in the PYGM gene [review]

  2. study found that T lymphocytes expressed myophosphorylase in healthy donors, but expression was significantly lower in McArdle patients (p<0.001); PYGM mRNA levels were also lower in white blood cells from McArdle patients

  3. biological significance of this PKCtheta (show PRKCQ Proteins);/alphaPIX (show ARHGEF6 Proteins)/Rac 1 GTPase (show RACGAP1 Proteins)/PYGM signaling pathway seems to be the control of different cellular responses such as migration and proliferation

  4. 5 different PYGM mutations were found in 8 Brazilian families: 4 previously described (p.R50X, p.T692kfs30, p.K609K, and p.G455R), and one, pI513V, a novel heterozygous mutation.

  5. a novel mutation, in the PYGM gene c.632delG, in three unrelated families of Jewish descent originating from the Caucasus region

  6. a new role for Rac1 in cell signaling, showing that this GTPase (show RACGAP1 Proteins) triggers T-cell proliferation upon IL-2 (show IL2 Proteins) stimulation by associating with PYGM and modulating its enzymatic activity.

  7. No genotype-phenotype correlation is evident and that no gender effect is related to the phenotype of McArdle's disease (PYGM gene) in a cohort of 123 European McArdle's disease patients.

  8. The current data add to the list of pathogenic mutations in the PYGM gene associated with McArdle disease

  9. This study demonistrated that PYGM mutation in McArdle disease.

  10. two new mutations in the myophosphorylase gene in Italian patients with McArdle's disease; both were compound heterozygous, with the common mutation at codon 49 (R49X) on the other allele

Pig (Porcine) Phosphorylase, Glycogen, Muscle (PYGM) interaction partners

  1. Data indicate that a G/T mutation in exon 8 in muscle glycogen phosphorylase (PYGM) was identified and association analysis with meat quality traits showed that it was significantly associated with lean meat percentage(p<0.05).

Phosphorylase, Glycogen, Muscle (PYGM) Protein Profile

Protein Summary

This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PYGM

  • phosphorylase, glycogen, muscle (PYGM)
  • glycogen phosphorylase, muscle form (THA_70)
  • muscle glycogen phosphorylase (Pygm)
  • phosphorylase, glycogen (muscle) A (pygma)
  • phosphorylase, glycogen, muscle (Pygm)
  • AI115133 protein
  • im:7150327 protein
  • Muscpho protein
  • PG protein
  • zgc:110706 protein

Protein level used designations for PYGM

glycogen phosphorylase , glycogen phosphorylase, muscle form , phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) , phosphorylase, glycogen. muscle , myophosphorylase , Phosphorylase glycogen , Phosphorylase, glycogen; muscle (McArdle syndrome) , muscle (McArdle syndrome) , muscle glycogen phosphorylase , glycogen myophosphorylase

GENE ID SPECIES
100050345 Equus caballus
451299 Pan troglodytes
7070860 Thermosipho africanus TCF52B
100137469 Papio anubis
19309 Mus musculus
553655 Danio rerio
100008972 Oryctolagus cuniculus
5837 Homo sapiens
24701 Rattus norvegicus
611078 Canis lupus familiaris
733659 Sus scrofa
327664 Bos taurus
442998 Ovis aries
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