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PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Additionally we are shipping PLAU Antibodies (336) and PLAU Proteins (58) and many more products for this protein.
Showing 10 out of 88 products:
Human PLAU ELISA Kit for Sandwich ELISA - ABIN414931
Russo, Pietsch: Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD). in Biomarker insights 2013
Show all 5 references for ABIN414931
Okada, Grobmyer, Barnathan: Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion. in Arteriosclerosis, thrombosis, and vascular biology 1996
Show all 4 references for ABIN612651
Duffy, Reilly, OSullivan, OHiggins, Fennelly, Andreasen: Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer. in Cancer research 1990
Show all 3 references for ABIN612650
Mouse (Murine) PLAU ELISA Kit for Sandwich ELISA - ABIN415604
Kim, Hong, Eom, Lee, Park: Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. in Breast cancer research and treatment 2011
In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 (show MMP9 ELISA Kits) by mesenchymal stromal cells.
Transplantation of uPA (show PRAP1 ELISA Kits) gene modified mesenchymal stem cells suppressed liver fibrosis and ameliorated liver function and may be a new approach to treating liver fibrosis
ApaL1 and Taq1 single nucleotide polymorphisms of the urokinase and VDR (show CYP27B1 ELISA Kits) genes are associated with recurrent urolithiasis in a Caucasian population.
1,25D3 works as a modifier of NF-kappaB (show NFKB1 ELISA Kits)/GPX1 (show GPX1 ELISA Kits)/uPA (show PRAP1 ELISA Kits) expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells
Resveratrol inhibited hypoxia-induced HIF-1alpha (show HIF1A ELISA Kits) protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 ELISA Kits) and MMP2 (show MMP2 ELISA Kits).
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
These findings strongly support the use of uPA (show PRAP1 ELISA Kits)/PAI-1 (show SERPINE1 ELISA Kits) together with clinic-pathological parameters as an evidence-based, clinically relevant and inexpensive decision tool in the routine of a breast center.
Data suggest that enhanced levels of uPA (show PRAP1 ELISA Kits) in breast cancer modulate the mitogenic effects of EGF (show EGF ELISA Kits) which helps to better understand breast cancer pathogenesis.
Results found high levels of uPA (show PRAP1 ELISA Kits) and uPAR (show PLAUR ELISA Kits) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 ELISA Kits)/uPAR (show PLAUR ELISA Kits) axis in an autocrine and paracrine fashion.
The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) and in some cases the enhanced activity of uPA (show PRAP1 ELISA Kits) and ACE (show ACE ELISA Kits), which makes an additional contribution to the increased invasive potential of tumor
GM-CSF (show CSF2 ELISA Kits) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR ELISA Kits))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (show PLAT ELISA Kits) and/or PAI-1 (show SERPINE1 ELISA Kits), rather than an altered uPA expression, determines the plasmin (show PLG ELISA Kits)-mediated Abeta (show APP ELISA Kits) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
beta-elemene downregulates expression of uPA, uPAR (show PLAUR ELISA Kits), MMP-2 (show MMP2 ELISA Kits), and MMP-9 (show MMP9 ELISA Kits) in a murine intraocular melanoma model
Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (show PLAT ELISA Kits)) followed by delayed synthesis and release of urokinase plasminogen (show PLG ELISA Kits) activator (uPA) from injured brain.
Binding of urokinase to urokinase plasminogen activator receptor (show PLAUR ELISA Kits) promotes dendritic spine recovery and functional outcome after ischemic stroke.
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (show PLAUR ELISA Kits)) and plasminogen activator inhibitor-1 (PAI-1 (show SERPINE1 ELISA Kits)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (show PLAUR ELISA Kits) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (show IRF6 ELISA Kits) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR ELISA Kits) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (show PLG ELISA Kits) activator/plasmin (show PLG ELISA Kits) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 ELISA Kits) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein