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PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Additionally we are shipping PLAU Antibodies (334) and PLAU Proteins (56) and many more products for this protein.
Showing 10 out of 99 products:
Okada, Grobmyer, Barnathan: Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion. in Arteriosclerosis, thrombosis, and vascular biology 1996
Show all 4 references for ABIN612651
Human PLAU ELISA Kit for Sandwich ELISA - ABIN414931
Russo, Pietsch: Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD). in Biomarker insights 2013
Show all 3 references for ABIN414931
Duffy, Reilly, OSullivan, OHiggins, Fennelly, Andreasen: Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer. in Cancer research 1990
Show all 3 references for ABIN612650
Siefert, Chabasse, Mukhopadhyay, Hoofnagle, Strickland, Sarkar, Antalis: Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice. in Journal of thrombosis and haemostasis : JTH 2014
Khan, Gupta, Kumar, Sharma, Kumar, Sharma: Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression. in Clinical & experimental metastasis 2014
Mouse (Murine) PLAU ELISA Kit for Sandwich ELISA - ABIN415604
Kim, Hong, Eom, Lee, Park: Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. in Breast cancer research and treatment 2011
Data suggest that enhanced levels of uPA (show PRAP1 ELISA Kits) in breast cancer modulate the mitogenic effects of EGF (show EGF ELISA Kits) which helps to better understand breast cancer pathogenesis.
Results found high levels of uPA (show PRAP1 ELISA Kits) and uPAR (show PLAUR ELISA Kits) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 ELISA Kits)/uPAR (show PLAUR ELISA Kits) axis in an autocrine and paracrine fashion.
The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) and in some cases the enhanced activity of uPA (show PRAP1 ELISA Kits) and ACE (show ACE ELISA Kits), which makes an additional contribution to the increased invasive potential of tumor
Crystal structure of uPA (show PRAP1 ELISA Kits) bound with cyclic peptidic inhibitors.
data on the stromal macrophages immunoreactivity of uPAR (show PLAUR ELISA Kits), MMP-2 (show MMP2 ELISA Kits), and MMP-9 (show MMP9 ELISA Kits) in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) biopsies was included. uPAR (show PLAUR ELISA Kits), MMP-2 (show MMP2 ELISA Kits), and MMP-9 (show MMP9 ELISA Kits) were confirmed in stromal cells including macrophages
u-PA is a dysregulated gene involved in the tumorigenesis, bio-pathological features and outcomes of EEC.
High cytoplasmic expression of uPA (show PRAP1 ELISA Kits) is associated with cells of rectal cancer and metastases of perienteric lymph nodes.
DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA (show PRAP1 ELISA Kits) and MMP9 (show MMP9 ELISA Kits) mediated by suppression of the transcription factor FOXM1 (show FOXM1 ELISA Kits)
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA (show PRAP1 ELISA Kits).
Taking uPA (show PRAP1 ELISA Kits)(1-43) amino acids specifically binding to uPAR (show PLAUR ELISA Kits) as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it (show KRT20 ELISA Kits) was able to inhibit growth of ovarian tumors .
GM-CSF (show CSF2 ELISA Kits) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR ELISA Kits))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (show PLAT ELISA Kits) and/or PAI-1 (show SERPINE1 ELISA Kits), rather than an altered uPA expression, determines the plasmin (show PLG ELISA Kits)-mediated Abeta (show APP ELISA Kits) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
beta-elemene downregulates expression of uPA, uPAR (show PLAUR ELISA Kits), MMP-2 (show MMP2 ELISA Kits), and MMP-9 (show MMP9 ELISA Kits) in a murine intraocular melanoma model
Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (show PLAT ELISA Kits)) followed by delayed synthesis and release of urokinase plasminogen (show PLG ELISA Kits) activator (uPA) from injured brain.
Binding of urokinase to urokinase plasminogen activator receptor (show PLAUR ELISA Kits) promotes dendritic spine recovery and functional outcome after ischemic stroke.
Protein kinase C-delta (show PKCd ELISA Kits) mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
uPA/uPAR (show PLAUR ELISA Kits) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (show IRF6 ELISA Kits) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR ELISA Kits) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (show PLG ELISA Kits) activator/plasmin (show PLG ELISA Kits) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 ELISA Kits) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein