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anti-Platelet Factor 4 (PF4) Antibodies

PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Kits (85) and Platelet Factor 4 Proteins (76) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PF4 5196 P02776
PF4 56744 Q9Z126
PF4 360918 P06765
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Top anti-Platelet Factor 4 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Biotin EIA, WB   0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated EIA, WB   0.2 mg Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PF4 antibody, Western blotting Lane 1: Recombinant Human CXCL4 Pr... Anti-PF4 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Mouse Un-conjugated WB Detection limit for recombinant GST tagged PF4 is approximately 1 ng/m... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Biotin EIA, WB   25 μg Log in to see 6 to 8 Days
$286.00
Details
Mouse Rabbit Biotin IHC, ELISA, WB 100 μg Log in to see 11 to 13 Days
$277.20
Details
Human Rabbit Un-conjugated EIA, Func, IHC (p), WB   50 μg Log in to see 6 to 8 Days
$286.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), ELISA, IHC (p), WB 100 μg Log in to see 11 to 13 Days
$308.00
Details
Human Rabbit Biotin IHC, ELISA, WB 100 μg Log in to see 11 to 13 Days
$338.80
Details
Human Sheep Un-conjugated ELISA, IHC (p) Human Placenta (formalin-fixed, paraffin-embedded) stained with PF4 an... 50 μg Log in to see 8 to 10 Days
$451.00
Details

PF4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Platelet Factor 4 Antibodies

  1. Human Monoclonal PF4 Primary Antibody for EIA, WB - ABIN954174 : Arepally, Kamei, Park, Kamei, Li, Liu, Siegel, Kisiel, Cines, Poncz: Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. in Blood 2000 (PubMed)
    Show all 6 references for ABIN954174

  2. Human Monoclonal PF4 Primary Antibody for EIA, WB - ABIN954175 : Suvarna, Rauova, McCracken, Goss, Sachais, McKenzie, Reilly, Gunn, Cines, Poncz, Arepally: PF4/heparin complexes are T cell-dependent antigens. in Blood 2005 (PubMed)
    Show all 6 references for ABIN954175

More Antibodies against Platelet Factor 4 Interaction Partners

Human Platelet Factor 4 (PF4) interaction partners

  1. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  2. A subset of heparin-treated patients produce subthreshold levels of platelet-activating anti-PF4/heparin antibodies that do not cause heparin-induced thrombocytopenia.

  3. Synovial Cxcl4 mRNA and protein were increased in early rheumatoid arthritis compared to uninflamed controls and resolving arthritis.

  4. Results found that CXCL4 plasma levels did not differ between patients with and without coronary artery disease. Also, no association between CXCL4 levels and plaque characteristics including plaque volume, calcium score, or vascular remodeling.

  5. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  6. PF4-heparin complexes can elicit a TLR4 (show TLR4 Antibodies)-mediated response, suggesting that these complexes can mimic a pathogen-associated molecular pattern, and supporting the suggestion that the HIT immune response represents a misdirected host defense mechanism.

  7. CXCL4 insufficiency may be involved in specific inflammatory microenvironment of ovarian cancers arising in endometriosis.

  8. although all HIT antibodies recognize PF4 in a complex with heparin, only a subset of these antibodies recognize more subtle epitopes induced in PF4 when it binds to CS, the major platelet glycosaminoglycan

  9. The interaction of PF4 with unfractionated heparin (UFH), its 16-, 8-, and 6-mer (show MERTK Antibodies) subfractions, low-molecular-weight heparin (LMWH), and the pentasaccharide fondaparinux, was characterized.

  10. CXCL4 and CXCL4L1 (show PF4V1 Antibodies) activated p38 MAPK (show MAPK14 Antibodies), as well as Src kinase (show CSK Antibodies) within 30 and 5 min, respectively. Extracellular signal-regulated kinase (ERK (show EPHB2 Antibodies)) phosphorylation occurred in activated lymphocytes.

Mouse (Murine) Platelet Factor 4 (PF4) interaction partners

  1. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  2. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  3. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

  4. CXCL4 regulates hematopoietic stem cell cell cycle activity.

  5. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection

  6. Histones regulate activated protein C (show PROC Antibodies) formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  7. PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.

  8. Peptide inhibition of CXCL4-CCL5 (show CCL5 Antibodies) interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms.

  9. PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage.

  10. These results suggest that Cxcl4 and Cxcl7 (show PPBP Antibodies) play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

Platelet Factor 4 (PF4) Antigen Profile

Protein Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.

Gene names and symbols associated with anti-Platelet Factor 4 (PF4) Antibodies

  • platelet factor 4 (PF4) antibody
  • platelet factor 4 (Pf4) antibody
  • Cxcl4 antibody
  • PF-4 antibody
  • Pf4a antibody
  • RATPF4A antibody
  • Scyb4 antibody

Protein level used designations for anti-Platelet Factor 4 (PF4) Antibodies

platelet factor 4 (chemokine (C-X-C motif) ligand 4) , C-X-C motif chemokine 4 , chemokine (C-X-C motif) ligand 4 , iroplact , oncostatin-A , PF-4

GENE ID SPECIES
703451 Macaca mulatta
740477 Pan troglodytes
5196 Homo sapiens
56744 Mus musculus
360918 Rattus norvegicus
507790 Bos taurus
101104401 Ovis aries
Selected quality suppliers for anti-Platelet Factor 4 (PF4) Antibodies
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