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PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Antibodies (115) and Platelet Factor 4 Kits (86) and many more products for this protein.
Showing 10 out of 74 products:
Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666881
Lasagni, Francalanci, Annunziato, Lazzeri, Giannini, Cosmi, Sagrinati, Mazzinghi, Orlando, Maggi, Marra, Romagnani, Serio, Romagnani: An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. in The Journal of experimental medicine 2003
Show all 10 references for ABIN2666881
Mouse (Murine) PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666923
Maione, Gray, Petro, Hunt, Donner, Bauer, Carson, Sharpe: Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. in Science (New York, N.Y.) 1990
Show all 10 references for ABIN2666923
Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2003519
ODonovan, Galvin, Morgan: Physical mapping of the CXC chemokine locus on human chromosome 4. in Cytogenetics and cell genetics 1999
Data suggest that, in patients with hypothyroid autoimmune thyroiditis, PF4/CXCL4 serum levels are significantly lower in those with subclinical hypothyroidism than in euthyroid control subjects.
Expression of CXCL4 and aquaporin 3 (show AQP3 Proteins) and 10 mRNAs in middle ear effusion is associated with the pathophysiology of otitis media with effusion.
PF4 changed its structure upon binding to polyP in a similar way as seen in PF4/heparin complexes. PF4/polyP complexes exposed neoepitopes to which human anti-PF4/heparin antibodies bound.
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
A subset of heparin-treated patients produce subthreshold levels of platelet-activating anti-PF4/heparin antibodies that do not cause heparin-induced thrombocytopenia.
Synovial Cxcl4 mRNA and protein were increased in early rheumatoid arthritis compared to uninflamed controls and resolving arthritis.
Results found that CXCL4 plasma levels did not differ between patients with and without coronary artery disease. Also, no association between CXCL4 levels and plaque characteristics including plaque volume, calcium score, or vascular remodeling.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
PF4-heparin complexes can elicit a TLR4 (show TLR4 Proteins)-mediated response, suggesting that these complexes can mimic a pathogen-associated molecular pattern, and supporting the suggestion that the HIT immune response represents a misdirected host defense mechanism.
CXCL4 insufficiency may be involved in specific inflammatory microenvironment of ovarian cancers arising in endometriosis.
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.
CXCL4 regulates hematopoietic stem cell cell cycle activity.
Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection
Histones regulate activated protein C (show PROC Proteins) formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.
PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.
Peptide inhibition of CXCL4-CCL5 (show CCL5 Proteins) interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms.
PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage.
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4