You are viewing an incomplete version of our website. Please click to reload the website as full version.

Platelet Factor 4 Proteins (PF4)

PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Antibodies (117) and Platelet Factor 4 Kits (86) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PF4 5196 P02776
PF4 56744 Q9Z126
PF4 360918 P06765
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Platelet Factor 4 Proteins at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 10 to 12 Days
$635.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$135.88
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Human Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$514.50
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)
,
Rat (Rattus) ,
,

Top referenced Platelet Factor 4 Proteins

  1. Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666881 : Lasagni, Francalanci, Annunziato, Lazzeri, Giannini, Cosmi, Sagrinati, Mazzinghi, Orlando, Maggi, Marra, Romagnani, Serio, Romagnani: An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. in The Journal of experimental medicine 2003 (PubMed)
    Show all 10 references for ABIN2666881

  2. Mouse (Murine) PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666923 : Maione, Gray, Petro, Hunt, Donner, Bauer, Carson, Sharpe: Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. in Science (New York, N.Y.) 1990 (PubMed)
    Show all 10 references for ABIN2666923

  3. Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2003519 : ODonovan, Galvin, Morgan: Physical mapping of the CXC chemokine locus on human chromosome 4. in Cytogenetics and cell genetics 1999 (PubMed)

More Proteins for Platelet Factor 4 (PF4) Interaction Partners

Human Platelet Factor 4 (PF4) interaction partners

  1. Data suggest that, in patients with hypothyroid autoimmune thyroiditis, PF4/CXCL4 serum levels are significantly lower in those with subclinical hypothyroidism than in euthyroid control subjects.

  2. Expression of CXCL4 and aquaporin 3 (show AQP3 Proteins) and 10 mRNAs in middle ear effusion is associated with the pathophysiology of otitis media with effusion.

  3. PF4 changed its structure upon binding to polyP in a similar way as seen in PF4/heparin complexes. PF4/polyP complexes exposed neoepitopes to which human anti-PF4/heparin antibodies bound.

  4. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  5. A subset of heparin-treated patients produce subthreshold levels of platelet-activating anti-PF4/heparin antibodies that do not cause heparin-induced thrombocytopenia.

  6. Synovial Cxcl4 mRNA and protein were increased in early rheumatoid arthritis compared to uninflamed controls and resolving arthritis.

  7. Results found that CXCL4 plasma levels did not differ between patients with and without coronary artery disease. Also, no association between CXCL4 levels and plaque characteristics including plaque volume, calcium score, or vascular remodeling.

  8. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  9. PF4-heparin complexes can elicit a TLR4 (show TLR4 Proteins)-mediated response, suggesting that these complexes can mimic a pathogen-associated molecular pattern, and supporting the suggestion that the HIT immune response represents a misdirected host defense mechanism.

  10. CXCL4 insufficiency may be involved in specific inflammatory microenvironment of ovarian cancers arising in endometriosis.

Mouse (Murine) Platelet Factor 4 (PF4) interaction partners

  1. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

  2. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  3. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  4. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

  5. CXCL4 regulates hematopoietic stem cell cell cycle activity.

  6. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection

  7. Histones regulate activated protein C (show PROC Proteins) formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  8. PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.

  9. Peptide inhibition of CXCL4-CCL5 (show CCL5 Proteins) interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms.

  10. PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage.

Platelet Factor 4 (PF4) Protein Profile

Protein Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.

Gene names and symbols associated with Platelet Factor 4 Proteins (PF4)

  • platelet factor 4 (PF4)
  • platelet factor 4 (Pf4)
  • Cxcl4 protein
  • PF-4 protein
  • Pf4a protein
  • RATPF4A protein
  • Scyb4 protein

Protein level used designations for Platelet Factor 4 Proteins (PF4)

platelet factor 4 (chemokine (C-X-C motif) ligand 4) , C-X-C motif chemokine 4 , chemokine (C-X-C motif) ligand 4 , iroplact , oncostatin-A , PF-4

GENE ID SPECIES
703451 Macaca mulatta
740477 Pan troglodytes
5196 Homo sapiens
56744 Mus musculus
360918 Rattus norvegicus
507790 Bos taurus
101104401 Ovis aries
Selected quality suppliers for Platelet Factor 4 Proteins (PF4)
Did you look for something else?