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PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. Additionally we are shipping PLAGL1 Proteins (7) and PLAGL1 Kits (3) and many more products for this protein.
Showing 10 out of 44 products:
Chicken Polyclonal PLAGL1 Primary Antibody for WB - ABIN2780800
Poulin, Labelle: The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors. in Cancer letters 2005
Human Monoclonal PLAGL1 Primary Antibody for ELISA, WB - ABIN1724868
Liu, Hsieh, Liu, Chang, Lin, Wang, Huang: Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells. in Experimental cell research 2011
Human Polyclonal PLAGL1 Primary Antibody for ELISA, WB - ABIN1535506
Abdollahi, Roberts, Godwin, Schultz, Sonoda, Testa, Hamilton: Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. in Oncogene 1997
Cow (Bovine) Polyclonal PLAGL1 Primary Antibody for WB - ABIN2792101
Lemeta, Jarmalaite, Pylkkänen, Böhling, Husgafvel-Pursiainen: Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma. in Journal of neuropathology and experimental neurology 2007
High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma (show MOK Antibodies).
Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC (show CALR Antibodies)) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC (show CALR Antibodies).
Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta.
DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma
There is positive correlations between the ZAC1 DMR (show WDR20 Antibodies) methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03).
ZAC1 and SSTR2 (show SSTR2 Antibodies) are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas.
Paternal methylation aberrations at imprinting control regions of DLK1 (show DLK1 Antibodies)-GTL2, MEST (PEG1 (show MEST Antibodies)), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages.
The imprinted PLAGL1 domain is flanked by CTCF (show CTCF Antibodies)-binding sites conserved between species in both expressing and non-expressing cells.
Based on these findings we conclude that the imprinted gene expression of KCNQ1OT1, CDKN1C (show CDKN1C Antibodies), H19 (show NCKAP1 Antibodies), and PLAGL1 are conserved between human and bovine
detected a synonymous variation in the protein-coding exon-2 of PLAGL1 in isolated VSD patients. It is possible that the etiology of isolated VSD might not be directly linked with this mutation
PLAGL1 is maternally imprinted in swine. Expression profiling using short-oligonucleotide microarrays of parthenotes and control fetal tissues supports imprinted isoform-specific expression.
The expression patterns of PLAGL1 and PEG10 (show PEG10 Antibodies) genes in two breeds of swine are reported.
Transcription factor MEF2 (show MEF2C Antibodies) and Zac1 mediate MIF (show MIF Antibodies)-induced GLUT4 (show SLC2A4 Antibodies) expression through CD74 (show CD74 Antibodies)-dependent AMPK (show PRKAA1 Antibodies) activation in cardiomyocytes
we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development
Zac1 interacts with two cis (show CISH Antibodies)-regulatory elements in the Tcf4 (show TCF4 Antibodies) gene locus.
results indicate ZAC is a negative regulator of the acute stimulatory effects of glucose on beta-cells. It provides an explanation for both insulin (show INS Antibodies) deficiency in the neonate and the later relapse of diabetes in patients with transient neonatal diabetes mellitus cases
Hymai and Plagl1it RNAs both have potentially high affinity for Trithorax (show MLLT1 Antibodies) chromatin regulators.
identified the guanine nucleotide exchange factor Rasgrf1 (show RASGRF1 Antibodies) as a direct Zac1/Plagl1 target gene in beta cells
Zac1 inhibits nuclear factor Kappa B activity by interacting with the C-terminus of the p65 (show NFkBP65 Antibodies) subunit, which suppresses the phosphorylation of p65 (show NFkBP65 Antibodies) at Ser468 and Ser536 residues
the different expression pattern of Zac1 in mice from human may explain the much milder phenotype in the mouse model of ZAC double dose
The Zac1 is a critical regulator of normal cerebellar development, adding a new transcriptional regulator to the growing list of factors involved in generating neuronal diversity in the developing cerebellum.
Plagl1/Zac1 gene is imprinted, with preferential expression from the paternal allele, and is one of a network of imprinted genes involved in the control of embryonic growth.
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.
pleiomorphic adenoma gene-like 1
, zinc finger protein PLAGL1-like
, PLAG-like 1
, lost on transformation 1
, pleiomorphic adenoma-like protein 1
, tumor suppressor ZAC
, tumor supressor ZAC
, zinc finger protein PLAGL1
, zinc finger protein Zac 1
, zinc finger protein regulator of apoptosis and cell cycle arrest
, Lost on transformation 1