anti-Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Antibodies

PABPC1 encodes a poly(A) binding protein. Additionally we are shipping Poly(A) Binding Protein, Cytoplasmic 1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PABPC1 26986 P11940
PABPC1 18458 P29341
PABPC1 171350 Q9EPH8
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Top anti-Poly(A) Binding Protein, Cytoplasmic 1 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-PABPC1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate Sample Type: Human brain stem cells (NT2) </br> <br />Primary Antibody Dilution: 1:500</br><br />Secondary Antibody: Goat anti-rabbit Alexa Fluor 594</br> <br />Secondary Antibody Dilution: 1:0000</br>Color/Signal Descriptions: Red: PABPC1 Blue: DAPI</br> <br /> Gene Name: PABPC1</br> <br /><br />Submitted by: Dr. Yuzhi Chen, University of Arkansas for Medical Science 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Mouse Un-conjugated CyTOF, ELISA, FACS, ICC, IF, IP, MA, WB Western Blot: PABP Antibody (10E10) [ABIN267505] - Cell line lysates were separated on SDS-PAGE and probed with 1 ug/mL Monoclonal Anti-PABP Clone: 10E10. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. (1) HEK293T, (2) HeLa, (3) G361 and (4) COS-7. Immunocytochemistry/Immunofluorescence: PABP Antibody (10E10) [ABIN267505] - PABP antibody was tested in HeLa cells at a 1:50 dilution using a Dylight 488 conjugated secondary antibody (Green). Actin (Red) and DNA (Blue) were counterstained using Phalloidin 568 and DAPI. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PABPC1 Antibody (Center) (ABIN389462) in NIH-3T3 cell line lysates (35 µg/lane). PABPC1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PABPC1 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Mouse Un-conjugated ICC, FACS, IF, IP, ELISA, WB Western blot for anti-PABP on HeLa cell extracts (left lane) 50 μL Log in to see 7 to 8 Days
$402.29
Details
Chicken Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB 100 μL Log in to see 16 Days
$460.63
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. PABP antibody [N1N2], N-term , dilution: 1:500. IHC-P Image PABP antibody [N1N2], N-term detects PABP protein at cytosol on mouse duodenum by immunohistochemical analysis. Sample: Paraffin-embedded mouse duodenum. PABP antibody [N1N2], N-term , dilution: 1:500. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Lane 1: mouse heart lysates Lane 2: mouse kidney lysates probed with Anti PABP (Methyl Arg455/460) Polyclonal Antibody, Unconjugated (ABIN704831) at 1:200 in 4C. Followed by conjugation to secondary antibody at 1:3000 90min in 37C. Predicted band 75kD. Observed band size: 75kD Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. 100 μL Log in to see 3 to 7 Days
$317.90
Details
Chicken Mouse Un-conjugated IF, IP, ELISA, WB 50 μL Log in to see 7 to 9 Days
$573.83
Details

PABPC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Poly(A) Binding Protein, Cytoplasmic 1 Antibodies

  1. Cow (Bovine) Monoclonal PABPC1 Primary Antibody for CyTOF, ELISA - ABIN267505 : Lee, Bedford: PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. in EMBO reports 2002 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108538 : Görlach, Burd, Dreyfuss: The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. in Experimental cell research 1994 (PubMed)
    Show all 3 Pubmed References

  3. Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108539 : Gorgoni, Richardson, Burgess, Anderson, Wilkie, Gautier, Martins, Brook, Sheets, Gray: Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal PABPC1 Primary Antibody for IF, WB - ABIN525792 : Higashi, Tomigahara, Shiraki, Miyata, Mikami, Kimura, Moro, Inagaki, Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. in The Journal of biological chemistry 2011 (PubMed)

More Antibodies against Poly(A) Binding Protein, Cytoplasmic 1 Interaction Partners

Human Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. Data suggest that DEAD-box helicase 3 (DDX3X (show DDX3X Antibodies)) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (show BLZF1 Antibodies) 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (show DDX3X Antibodies) (via gene silencing with the CRISPR-Cas (show CSE1L Antibodies) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.

  2. Data suggest that hnRNPLL (show HNRPLL Antibodies) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (show HNRPLL Antibodies) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (show HNRPLL Antibodies) = heterogeneous nuclear ribonucleoprotein L-like (show HNRPLL Antibodies) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  3. PABP enhances the productive binding of the eRF1 (show ZFP36L1 Antibodies)-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a (show GSPT1 Antibodies) which itself has an active role in translation termination.

  4. Unr (show P2RY4 Antibodies) stimulated the binding of PABP1 to mRNA, and that Unr (show P2RY4 Antibodies) was required for the stable interaction of PABP1 and eIF4G (show EIF4G1 Antibodies) in cells.

  5. PABPC1 decreased expression in in infertile men with non-obstructive azoospermia

  6. BTG2 (show BTG2 Antibodies) stimulates mRNA deadenylation via CAF1 (show CHAF1B Antibodies) activation through interaction with PABPC1. Interaction of BTG2 (show BTG2 Antibodies) with the first RRM domain of PABPC1 is required for BTG2 (show BTG2 Antibodies) to control cell proliferation.

  7. PABPC1 is a novel co-regulator of the AR

  8. PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis.

  9. PABPC1 interacts with AGO2 (show EIF2C2 Antibodies) and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.

  10. Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus

Mouse (Murine) Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. Data suggest that hnRNPLL (show HNRPLL Antibodies) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (show HNRPLL Antibodies) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (show HNRPLL Antibodies) = heterogeneous nuclear ribonucleoprotein L-like (show HNRPLL Antibodies) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  2. Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.

  3. Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (show EGFR Antibodies) signaling.

  4. Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells

  5. These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB

  6. Epab is dispensable for mouse spermatogenesis and male fertility.

  7. We analyzed the expression of sperm-specific Akap3 (show AKAP3 Antibodies) and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  8. Both Epab and Pabpc1 expression increase during early postnatal life and reach their peak at D32 testis.

  9. our data support the concept that expanded ATXN2 (show ATXN2 Antibodies) undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (show FBXW8 Antibodies).

  10. EPAB is necessary for oogenesis, folliculogenesis and female fertility in mice.

Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Antigen Profile

Protein Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

Gene names and symbols associated with PABPC1

  • poly(A) binding protein, cytoplasmic 1-like (pabpc1l) antibody
  • poly(A) binding protein, cytoplasmic 1 (pabpc1) antibody
  • poly(A) binding protein, cytoplasmic 1-like (PABPC1L) antibody
  • poly A binding protein, cytoplasmic 1 a (pabpc1a) antibody
  • poly(A) binding protein, cytoplasmic 1 (pabpc1-a) antibody
  • poly(A) binding protein, cytoplasmic 1 (PABPC1) antibody
  • poly(A) binding protein, cytoplasmic 1 (Pabpc1) antibody
  • ePAB antibody
  • fi20g03 antibody
  • pab-2 antibody
  • PAB1 antibody
  • Pabp antibody
  • Pabp1 antibody
  • pabpc1 antibody
  • PABPC2 antibody
  • PabpI antibody
  • Pabpl1 antibody
  • wu:fb16a02 antibody
  • wu:fi19b08 antibody
  • wu:fi20g03 antibody
  • wu:fj12d09 antibody
  • wu:fj61f06 antibody
  • zgc:55855 antibody
  • zgc:109879 antibody

Protein level used designations for PABPC1

polyadenylate-binding protein 1-like , poly(A) binding protein, cytoplasmic 1 , polyadenylate-binding protein 1 , PABP 1-A , PABP-1-A , PABP-A , cytoplasmic poly(A)-binding protein 1-A , poly(A)-binding protein 1-A , polyadenylate-binding protein 1-A , xPABP1-A , poly(A) binding protein, cytoplasmic 2 , PABP 1 , PABP-1 , poly(A)-binding protein 1 , poly A binding protein 1

GENE ID SPECIES
327625 Danio rerio
448595 Xenopus (Silurana) tropicalis
711882 Macaca mulatta
606498 Danio rerio
379896 Xenopus laevis
430997 Gallus gallus
26986 Homo sapiens
612751 Canis lupus familiaris
282296 Bos taurus
18458 Mus musculus
171350 Rattus norvegicus
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