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PABPC1 encodes a poly(A) binding protein. Additionally we are shipping Poly(A) Binding Protein, Cytoplasmic 1 Proteins (10) and many more products for this protein.
Showing 10 out of 65 products:
Cow (Bovine) Monoclonal PABPC1 Primary Antibody for CyTOF, ELISA - ABIN267505
Lee, Bedford: PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. in EMBO reports 2002
Show all 7 references for ABIN267505
Chicken Monoclonal PABPC1 Primary Antibody for ICC, FACS - ABIN108539
Görlach, Burd, Dreyfuss: The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. in Experimental cell research 1994
Show all 3 references for ABIN108539
Human Polyclonal PABPC1 Primary Antibody for EIA, WB - ABIN453247
Le Clerc, Limou, Coulonges, Carpentier, Dina, Taing, Delaneau, Labib, Sladek, , Deveau, Guillemain, Ratsimandresy, Montes, Spadoni, Therwath, Schächter, Matsuda, Gut, Lelièvre, Lévy, Froguel, Delfraissy, Hercberg, Zagury: Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). in The Journal of infectious diseases 2009
Human Polyclonal PABPC1 Primary Antibody for IF, WB - ABIN525792
Higashi, Tomigahara, Shiraki, Miyata, Mikami, Kimura, Moro, Inagaki, Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. in The Journal of biological chemistry 2011
Chicken Polyclonal PABPC1 Primary Antibody for IHC, WB - ABIN2778803
Rivera, Lloyd: Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors. in Virology 2008
Unr (show P2RY4 Antibodies) stimulated the binding of PABP1 to mRNA, and that Unr (show P2RY4 Antibodies) was required for the stable interaction of PABP1 and eIF4G (show EIF4G1 Antibodies) in cells.
PABPC1 decreased expression in in infertile men with non-obstructive azoospermia
BTG2 (show BTG2 Antibodies) stimulates mRNA deadenylation via CAF1 (show CHAF1B Antibodies) activation through interaction with PABPC1. Interaction of BTG2 (show BTG2 Antibodies) with the first RRM domain of PABPC1 is required for BTG2 (show BTG2 Antibodies) to control cell proliferation.
PABPC1 is a novel co-regulator of the AR
PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis.
PABPC1 interacts with AGO2 (show EIF2C2 Antibodies) and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.
Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus
Metastatic duodenal cancer cells do not tolerate intracellular PABP1 accumulation and are thus exported into the extracellular milieu by the exosome-mediated pathway. In addition, PABP1 has a potential use as a biomarker for metastatic duodenal cancer.
This study highlights PABP-1 as a protein that is important to the pathology of ALS and indicates that the proteomic profile of TDP-43 inclusions in ALS may differ depending on the causative genetic mutation.
PABPC1 is mislocalized in spinal cord motor neurons in amyotrophic lateral sclerosis.
Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.
Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (show EGFR Antibodies) signaling.
Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells
These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB
Epab is dispensable for mouse spermatogenesis and male fertility.
We analyzed the expression of sperm-specific Akap3 (show AKAP3 Antibodies) and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
Both Epab and Pabpc1 expression increase during early postnatal life and reach their peak at D32 testis.
our data support the concept that expanded ATXN2 (show ATXN2 Antibodies) undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (show FBXW8 Antibodies).
EPAB is necessary for oogenesis, folliculogenesis and female fertility in mice.
PABPC2 was present in pachytene spermatocytes and round spermatids, whereas elongating spermatids still included PABPC1.
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
polyadenylate-binding protein 1-like
, poly(A) binding protein, cytoplasmic 1
, polyadenylate-binding protein 1
, PABP 1-A
, cytoplasmic poly(A)-binding protein 1-A
, poly(A)-binding protein 1-A
, polyadenylate-binding protein 1-A
, poly(A) binding protein, cytoplasmic 2
, PABP 1
, poly(A)-binding protein 1
, poly A binding protein 1