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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. Additionally we are shipping PCBP1 Proteins (9) and PCBP1 Kits (4) and many more products for this protein.
Showing 10 out of 117 products:
Human Polyclonal PCBP1 Primary Antibody for ELISA, WB - ABIN562120
Neff, Lee, Wilusz, Tian, Wilusz: Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. in Genome research 2012
Show all 3 Pubmed References
Human Polyclonal PCBP1 Primary Antibody for ELISA, WB - ABIN4344018
Waggoner, Johannes, Liebhaber: Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. in The Journal of biological chemistry 2009
Human Monoclonal PCBP1 Primary Antibody for IF, ELISA - ABIN518653
Link, Howley, Hussey, Howe: PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. in Molecular cancer research : MCR 2016
Cow (Bovine) Polyclonal PCBP1 Primary Antibody for IHC, WB - ABIN2778971
Shi, Bencze, Stemmler, Philpott: A cytosolic iron chaperone that delivers iron to ferritin. in Science (New York, N.Y.) 2008
Study report a novel interaction between mutant HSPB1 (show HSPB1 Antibodies)-P182L and the RNA binding protein (show PTBP1 Antibodies) PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (show HSPB1 Antibodies) in neurodegenerative diseases.
It is reported here that TGF-beta (show TGFB1 Antibodies) directly regulates alternative splicing of cancer stem cell marker CD44 (show CD44 Antibodies) through a phosphorylated threonine179 of SMAD3 (show SMAD3 Antibodies)-mediated interaction with RNA-binding protein (show PTBP1 Antibodies) PCBP1.
our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer
Data suggest a 216-nucleotide proximal cis (show CISH Antibodies)-element in LIF (show LIF Antibodies) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Antibodies)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL Antibodies) and PCBP1, 2 trans-acting factors that bind to and stabilize LIF (show LIF Antibodies) mRNA. [LIF (show LIF Antibodies) = leukemia inhibitory factor (show LIF Antibodies); PCBP1 = poly(rC) binding protein 1]
It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.
TGF-beta (show TGFB1 Antibodies) signaling through Akt2 (show AKT2 Antibodies) induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis.
These results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (show TIA1 Antibodies), Pcbp1, and RBM39 (show RBM39 Antibodies) stabilizes or increases U2 snRNP (show LSM2 Antibodies) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39 (show RBM39 Antibodies)-mediated splicing regulation.
BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain.
Low expression of PCBP1 is associated with lung cancer metastasis.
Study report a novel interaction between mutant HSPB1 (show HSPB1 Antibodies)-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (show HSPB1 Antibodies) in neurodegenerative diseases.
These studies demonstrate the importance of ferritin (show FTL Antibodies) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 (show NCOA4 Antibodies) in mediating iron flux through ferritin (show FTL Antibodies).
Pcbp1 modulated the processing of muscle-enriched miR-1, miR (show MLXIP Antibodies)-133, and miR (show MLXIP Antibodies)-206 by physically interacting with argonaute 2 (AGO2 (show EIF2C2 Antibodies)) and other miRNA pathway components.
These data reveal that Pcbp1 and Pcbp2 (show PCBP2 Antibodies) are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP1 may serve as a novel maternal factor (show ZAR1 Antibodies).
Our analysis of PCBP1 and PCBP2 (show PCBP2 Antibodies) expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed
TGF-beta (show TGFB1 Antibodies) modulates the expression of Dab2 (show DAB2 Antibodies) and ILEI (show FAM3C Antibodies) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT (show BAAT Antibodies) element in the 3'UTR (show UTS2R Antibodies) of Dab2 (show DAB2 Antibodies) and ILEI (show FAM3C Antibodies).
To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB (show NFKB1 Antibodies) we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot (show SLC6A7 Antibodies) with specific for C-rich pyrimidine tracts
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
poly(rC) binding protein 1
, poly(rC)-binding protein 1-like
, heterogeneous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein X
, nucleic acid-binding protein SUB2.3
, poly(rC)-binding protein 1
, hnRNP-E1 protein
, hnRNP E1