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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antibodies

PKD1 encodes a member of the polycystin protein family. Additionally we are shipping Polycystic Kidney Disease 1 (Autosomal Dominant) Kits (4) and Polycystic Kidney Disease 1 (Autosomal Dominant) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PKD1 5310 P98161
PKD1 18763 O08852
PKD1 24650  
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Top anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-Polycystin 1 Polyclonal Antibody, Unconjugated (ABIN678083) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Goat Un-conjugated IHC (p) Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Kidney, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated IHC, ELISA   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

PKD1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antibodies

  1. Human Polyclonal PKD1 Primary Antibody for IF (p), IHC (p) - ABIN678083 : Chiou, Sang, Cheng, Ho, Wang, Pan: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. in Carcinogenesis 2013 (PubMed)
    Show all 2 references for ABIN678083

More Antibodies against Polycystic Kidney Disease 1 (Autosomal Dominant) Interaction Partners

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. Germline mutations in PKD1 gene is associated with autosomal-dominant polycystic kidney disease.

  2. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.

  3. PCs expression and p53 (show TP53 Antibodies) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.

  4. These results suggest that, at least in some patients, the severity of the cystic disease is inversely correlated with the level of polycystin 1 function.

  5. Overexpression of PKD1 in a prostate cancer cell line model resulted in decreased cell proliferation and epithelial mesenchymal transition.

  6. and MMP9 (show MMP9 Antibodies) expression in PKD1 constitutively-active MD-MB-231 cells and MCF-7 knockdown cells were decreased and increased respectively

  7. A substantial number of PKD1 missense or synonymous mutations characterize pre-mRNA splicing. One missense and 2 synonymous mutations induce significant defects in pre-mRNA splicing.

  8. PKD1 gene variation plays a disease modifying role in patients diagnosed with ADPKD.

  9. A short segment of chromosome 16 encodes the tumor suppressor gene tuberin (show TSC2 Antibodies) as well as the protein polycystin 1 which are responsible for tuberous sclerosis complex type 2 and autosomal-dominant polycystic kidney disease type 1, respectively.

  10. Case Report: polycystic kidney disease with steatocystoma multiplex. PKD1 mutations disrupt keratin 17 (show KRT17 Antibodies) polymerization.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  2. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.

  3. detected a marked increase in the localization of beta-catenin (show CTNNB1 Antibodies) in the nucleus of crypt epithelial cells in the ileum of PKD1

  4. PKD1 phosphorylates AMPKalpha2 (show PRKAA2 Antibodies) at Ser485/491, thus diminishing AMPK (show PRKAA1 Antibodies) activity.

  5. These data potentially explain the severe renal manifestations of the tuberous sclerosis/polycystic kidney disease contiguous gene syndrome and open new perspectives for the use of mTOR (show FRAP1 Antibodies) inhibitors in PKD (show PRKD1 Antibodies).

  6. Our results show that AKAP13 (show AKAP13 Antibodies)-PKD1 signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.

  7. PKD1 acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (show NOTCH1 Antibodies) pathway.

  8. Results reveal that whereas protein kinase D1 (show PRKD1 Antibodies) and protein kinase D2 (show PKD2 Antibodies) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  9. PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.

  10. novel protein complex composed of Rabep1 (show RABEP1 Antibodies), GGA1 (show GGA1 Antibodies) and Arl3 is responsible for the sorting and targeting of the polycystin 1 andpolycystin 2 to the cilium.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antigen Profile

Protein Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Gene names and symbols associated with PKD1

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) antibody
  • polycystic kidney disease 1 homolog (Pkd1) antibody
  • polycystic kidney disease 1 homolog (human) (Pkd1) antibody
  • protein kinase D1 (Prkd1) antibody
  • mFLJ00285 antibody
  • PBP antibody
  • Pc-1 antibody
  • PC1 antibody
  • Pkcm antibody
  • PKD antibody
  • PKD1 antibody
  • Prkcm antibody
  • TRPP1 antibody

Protein level used designations for PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPECIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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