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In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. Additionally we are shipping Polyhomeotic Homolog 2 (Drosophila) Proteins (5) and many more products for this protein.
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Human Monoclonal PhC2 Primary Antibody for ICC, IF - ABIN2668926
Isono, Fujimura, Shinga, Yamaki, O-Wang, Takihara, Murahashi, Takada, Mizutani-Koseki, Koseki: Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. in Molecular and cellular biology 2005
Show all 2 references for 2668926
these results propose a novel role of SIAH-1 in regulating the expression level of HPH2 through the ubiquitin-proteasome pathway.
polymerization of the Phc2 SAM (show TTN Antibodies) domain is required for PRC1 (show PRC1 Antibodies) clustering, chromatin condensation and gene silencing.
Phc2 may act as a negative regulator that inhibits the activity of Th cells.
functional overlap between Phc2 and Phc1 (show PHC1 Antibodies) along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning
Collectively, the data argue that ph2alpha is required for epiboly and tailbud formation, acting downstream of the FGF signaling pathway
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.
, polyhomeotic-like protein 2
, early development regulator 2 (homolog of polyhomeotic 2)
, early development regulatory protein 2
, polyhomeotic 2
, early development regulator 2
, polyhomeotic 2 protein