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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Additionally we are shipping Polyhomeotic Homolog 3 (Drosophila) Antibodies (10) and many more products for this protein.
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Data show that polycomb (show CBX2 Proteins)-group proteins BMI1 (show BMI1 Proteins), PHC3, CBX6 (show CBX6 Proteins) and CBX7 (show CBX7 Proteins) expression was significantly increased during imatinib treatment.
PHC3 amplification may emerge as a biomarker in cancer.
SAM (show TTN Proteins) linker controls PHC3 SAM (show TTN Proteins) polymerization
PHC3 is a tumor suppressor in osteosarcoma cells abd its suppression may be caused by modification of polycomb (show CBX2 Proteins) repressive complex 1 in cancer cells.
loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0)
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
polyhomeotic-like protein 3
, polyhomeotic like 3
, polyhomeotic homolog 3 (Drosophila)
, early development regulator 3
, early development regulatory protein 3
, homolog of polyhomeotic 3
, polyhomeotic 3