You are viewing an incomplete version of our website. Please click to reload the website as full version.

Polymerase (DNA Directed), gamma Proteins (POLG)

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Additionally we are shipping POLG Antibodies (55) and POLG Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POLG 5428 P54098
POLG 18975  
Rat POLG POLG 85472 Q9QYV8
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top POLG Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Mammalian Cells Human hepatitis A virus His tag 100 μg Log in to see 13 to 16 Days
$1,490.50
Details
HOST_Escherichia coli (E. coli) REACT_Human rhinovirus A His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast REACT_Human rhinovirus A His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

POLG Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Polymerase (DNA Directed), gamma (POLG) Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The stimulatory effect of mtSSB (show SSBP1 Proteins) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific (show EIF3K Proteins) overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (show SSBP1 Proteins) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (show RPA1 Proteins) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. CAG repeat (show CELF3 Proteins) polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) does not appear to be associated with colorectal cancer

  2. altered genetic and epigenetic regulation of POLG1 in human cancers and suggest a role for POLG1 germline variants in promoting tumorigenic properties.

  3. Herein we report a patient with a POLG gene W748S homozygous mutation and characteristic lesions in the thalamus, cerebellum and inferior olivary nucleus seen on magnetic resonance imaging.

  4. POLG's 3'-5' exonuclease (show EXOSC10 Proteins) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  5. The stimulatory effect of mtSSB (show SSBP1 Proteins) on Pol gamma on these ssDNA templates is not species-specific.

  6. Computational analysis of the PolG protein suggests that the p.K601E mutation is likely the most significant contributing factor to a pathogenic phenotype in an adult mitochondrial ataxia (show USP14 Proteins).

  7. Data suggest that methylation of mitochondrial DNA in exon 2 of POLGA is instrumental in regulation of DNA replication in pluripotent stem cells, in embryonic development, and in tumorigenesis. [REVIEW]

  8. Family case study and literature review of the complexity of genotype-phenotype correlations of POLG1 gene

  9. Multiple deletions of mitochondrial DNA were detected along with a novel mutation in POLG1 in patients with Parkinsonism, cognitive deficit and behavioral disturbance.

  10. The results of this study provided evidence for a significantly lower of mtDNA copy number in PD patients and POLG1 variation for reducing mtDNA copy number in Parkinson dseases.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  2. POLG's 3'-5' exonuclease (show EXOSC10 Proteins) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  3. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  4. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  5. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  6. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO and Alpers syndrome, and the exonuclease deficient pol-gamma (exo(-)) in premature aging mouse models.

  7. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  8. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (show EXOSC10 Proteins) activity is required for preserving mtDNA integrity.

  9. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

  10. Dnaja3 (show DNAJA3 Proteins) is crucial for mitochondrial biogenesis through its chaperone activity on Polga and has a role in preventing dilated cardiomyopathy

POLG Protein Profile

Protein Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • tamas (tam)
  • polymerase (DNA directed), gamma (POLG)
  • DNA polymerase gamma 35kD (DNApol-gamma35)
  • polymerase (DNA directed), gamma (polg)
  • polymerase (DNA directed), gamma (Polg)
  • 34Dc protein
  • AA409516 protein
  • AAC47658 protein
  • anon-34Dc protein
  • BG:DS00941.6 protein
  • BG:DS00941.9 protein
  • br5 protein
  • br16 protein
  • cDNA 2 protein
  • CG8969 protein
  • CG8987 protein
  • CG33084 protein
  • CG33650 protein
  • D-pol gamma-alpha protein
  • D-pol gamma-beta protein
  • Dmel\\CG8987 protein
  • Dmel\\CG33650 protein
  • DNA pol-gam.35 protein
  • DNApol-gamma protein
  • DNApol-gamma.35 protein
  • DNApol-gamma125 protein
  • l(2)34Dc protein
  • l(2)34De protein
  • l(2)br5 protein
  • l(2)br14 protein
  • l(2)br16 protein
  • l(2)brS protein
  • MDP1 protein
  • MIRAS protein
  • mtDNA pol protein
  • MTDPS4A protein
  • MTDPS4B protein
  • mtPolA protein
  • MtPolB protein
  • PEO protein
  • PolG protein
  • POLG1 protein
  • PolgA protein
  • polgamma protein
  • pol gamma protein
  • pol gamma-alpha protein
  • polgamma-alpha protein
  • polgamma-beta protein
  • pol gamma-beta protein
  • pol gamma35 protein
  • SANDO protein
  • SCAE protein
  • Tam protein

Protein level used designations for POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

GENE ID SPECIES
34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
Selected quality suppliers for POLG Proteins (POLG)
Did you look for something else?