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Potassium Channel, Subfamily T, Member 1 Proteins (KCNT1)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Channel, Subfamily T, Member 1 Antibodies (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNT1 57582 Q5JUK3
KCNT1 227632 Q6ZPR4
Rat KCNT1 KCNT1 60444 Q9Z258
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Top Potassium Channel, Subfamily T, Member 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

KCNT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Potassium Channel, Subfamily T, Member 1 (KCNT1) Interaction Partners

Human Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy.

  2. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy.

  3. Five de novo mutations were identified in four genes (SCNN1A (show SCNN1A Proteins), KCNJ16 (show KCNJ16 Proteins), KCNB2 (show KCNB2 Proteins), and KCNT1) in three Brugada syndrome patients (20%)

  4. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel (show KCNC4 Proteins) give rise to three distinct forms of epilepsy.

  5. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.

  6. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ (show PIGQ Proteins).

  7. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).

  8. This gene-wide tagging study revealed no association between KCNT1 17 common variations and susceptibility of GGEs or AEDs (anti-epileptic drugs) efficacy of genetic generalized epilepsies in Chinese population.

  9. This study demonistrated that KCNT1 mutations implicated in epilepsy cause a marked increase in function

  10. this study performed analysis of KCNT1 in two unrelated patients with malignant migrating partial seizures in infancy.Because the G-to-A transition was located at CG dinucleotide sequences as previously reported for KCNT1 mutations, the recurrent occurrence of de novo KCNT1 mutations indicated the hot spots of these locations.

Mouse (Murine) Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. The authors find that knockout of Slo2.2, but not Slo2.1, results in enhanced itch and pain responses.

  2. Results provide evidence for a role for endogenous Slack channels in higher brain functions, i.e., learning and memory, cognitive flexibility, locomotoric and the ability to initially respond to novel situations and environments

  3. Global ablation of Slack led to increased hypersensitivity in models of neuropathic pain. Neuropathic pain behaviors were also exaggerated after ablation of Slack selectively in sensory neurons.

  4. partly colocalized with PSD-95 (show DLG4 Proteins) in mouse neocortical neurons

  5. This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel (show KCNC4 Proteins) resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel (show KCNC4 Proteins) is located in the ascending limb of the kidney.

  6. Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.

Potassium Channel, Subfamily T, Member 1 (KCNT1) Protein Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KCNT1

  • potassium channel, subfamily T, member 1 (KCNT1)
  • potassium channel, subfamily T, member 1 (kcnt1)
  • potassium channel, subfamily T, member 1 (Kcnt1)
  • bA100C15.2 protein
  • C030030G16Rik protein
  • EIEE14 protein
  • ENFL5 protein
  • KCa4.1 protein
  • MGC146594 protein
  • MGC172997 protein
  • mKIAA1422 protein
  • rSlo2 protein
  • Slack protein
  • slo2 protein
  • Slo2.2 protein

Protein level used designations for KCNT1

potassium channel, subfamily T, member 1 , potassium channel subfamily T member 1-like , potassium channel subfamily T member 1 , sodium-activated potassium channel , potassium channel subunit (Slack) , sequence like a calcium-activated potassium channel subunit , potassium channel subunit

GENE ID SPECIES
100436526 Pongo abelii
100588032 Nomascus leucogenys
464846 Pan troglodytes
491258 Canis lupus familiaris
529468 Bos taurus
779818 Xenopus (Silurana) tropicalis
100016518 Monodelphis domestica
100316919 Xenopus (Silurana) tropicalis
57582 Homo sapiens
227632 Mus musculus
60444 Rattus norvegicus
395248 Gallus gallus
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