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KCNT1 Products

(Potassium Channel, Subfamily T, Member 1 (KCNT1))

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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

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Featured KCNT1 Categories

KCNT1 Antibodies

High quality antibodies with extensive validation data.

KCNT1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KCNT1 Antibodies

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Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IF, ICC, AA
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Cat. No. ABIN2482929
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IF, ICC, AA
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  • (4)
Cat. No. ABIN2482928
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IF, ICC, AA
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  • (4)
Cat. No. ABIN2482927
Quantity 100 μg
Datasheet Datasheet

Recommended KCNT1 Proteins

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Reactivity
Source
Validations
Cat. No.
Quantity
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Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3115360
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3135864
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our KCNT1 products

Lu, Bausch, Kallenborn-Gerhardt, Stoetzer, Debruin, Ruth, Geisslinger, Leffler, Lukowski, Schmidtko: "Slack channels expressed in sensory neurons control neuropathic pain in mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 3, pp. 1125-35, (2015) (PubMed).

Cervantes, Vega, Limón, Soto: "Identity, expression and functional role of the sodium-activated potassium current in vestibular ganglion afferent neurons." in: Neuroscience, Vol. 240, pp. 163-75, (2013) (PubMed).

Huang, Wang, Ostertag, Nuwal, Huang, Jan, Basbaum, Jan: "TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing." in: Nature neuroscience, Vol. 16, Issue 9, pp. 1284-90, (2013) (PubMed).

Zhang, Brown, Hyland, Chen, Kronengold, Fleming, Kohn, Moroz, Kaczmarek: "Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 44, pp. 15318-27, (2012) (PubMed).

Wojtovich, Sherman, Nadtochiy, Urciuoli, Brookes, Nehrke: "SLO-2 is cytoprotective and contributes to mitochondrial potassium transport." in: PLoS ONE, Vol. 6, Issue 12, pp. e28287, (2011) (PubMed).

Nuwer, Picchione, Bhattacharjee: "PKA-induced internalization of slack KNa channels produces dorsal root ganglion neuron hyperexcitability." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 42, pp. 14165-72, (2010) (PubMed).

Chen, Kronengold, Yan, Gazula, Brown, Ma, Ferreira, Yang, Bhattacharjee, Sigworth, Salkoff, Kaczmarek: "The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 17, pp. 5654-65, (2009) (PubMed).

Synonyms and alternative names related to KCNT1

potassium sodium-activated channel subfamily T member 1 (KCNT1), potassium channel subfamily T member 1 (LOC100436526), potassium sodium-activated channel subfamily T member 1 (Kcnt1), potassium channel, subfamily T, member 1 (Kcnt1), potassium channel, sodium activated subfamily T, member 1 (kcnt1), bA100C15.2, C030030G16Rik, EIEE14, ENFL5, KCa4.1, MGC146594, mKIAA1422, rSlo2, SLACK, Slack, slack, slo2, Slo2.2

Protein level used designations for KCNT1

  • potassium channel subfamily T member 1
  • potassium channel, subfamily T, member 1
  • potassium channel subfamily T member 1-like
  • potassium channel subunit (Slack)
  • sequence like a calcium-activated potassium channel subunit
  • sodium-activated potassium channel
  • potassium channel subunit
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