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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 Proteins (5) and many more products for this protein.
Showing 10 out of 65 products:
Mammalian Monoclonal KCNA4 Primary Antibody for ISt, IHC - ABIN1304751
Pott, Ren, Tran, Yang, Henderson, Jordan, Roos, Garfinkel, Philipson, Goldhaber: Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. in American journal of physiology. Cell physiology 2007
Show all 30 Pubmed References
Human Polyclonal KCNA4 Primary Antibody for WB - ABIN1881472
Lee, Lee, Choi, Yoon, Pyo, Shin, Choi, Lim, Rhim, Won, Lim, Choe, Kim, Kim, Nah: Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. in Molecular pharmacology 2008
Show all 3 Pubmed References
Expression of Kv1.4 appears to increase in the spinal cord of mice modelling remitting-relapsing experimental allergic encephalomyelitis (rrEAE) in peak and remitting phases.
Detection of the methylation prevalence of KCNA4 and CYP26B1 (show CYP26B1 Antibodies) together in serum demonstrated the good sensitivity and specificityin gastric cancer
Data suggest that episodic ataxia type 1 mutations affect fast inactivation of Kv1.1 (show KCNA1 Antibodies)/1.4 channels by a reduction in either subunit surface expression or altered affinity for the inactivation domain.
Sialylated N-glycans uniquely impact gating of a mammalian Shaker family K(v) channel isoform, K(v)1.5 (show KCNA5 Antibodies), but have no effect on gating of a second Shaker isoform, K(v)1.4.
Results describe an erbstatin (Erb (show ESR2 Antibodies)) analogue as a small molecule inhibitor of the N-type inactivation in potassium channels Kv1.4 and Kv1.1 (show KCNA1 Antibodies)+Kvbeta1 (show KCNAB1 Antibodies).
Novel role for GIP (show GIP Antibodies) in regulating K(V)1.4 cell surface expression and modulation of A-type potassium currents
Fast inactivation in human Kv1.4 is modulated by structural elements in the C-terminus, suggesting that the process involves the concerted action of the N- and C-termini.
The results demonstrate that the human Kvbeta1.1 (show KCNAB1 Antibodies) and Kvbeta1.2 subunits regulate the proportion of wild-type Kv1.4-1.1 channels that are available to open.
Ginsenoside Rg3 inhibits KV1.4 channel currents by interacting with the lysine531 residue.
Thr (show TRH Antibodies)-330 of Kv1.4 serves to interlock the voltage-sensing and gating domains of adjacent monomers, thereby yielding a structure competent for the surface expression of functional tetramers
Data show that suprachiasmatic nucleus (SCN (show SRI Antibodies)) explants from potassium channel (show KCNAB2 Antibodies) Kv1.4(-/-)period2 protein Per2 (show PER2 Antibodies)(Luc) and potassium channel Kv4.2 (show KCND2 Antibodies)(-/-) period2 protein Per2 (show PER2 Antibodies)(Luc) mice have significantly shorter circadian periods in PER2 (show PER2 Antibodies) rhythms.
Increased A-type K(+) currents and expression of voltage-gated potassium channel (show KCNQ1 Antibodies) Kcna4 (Kv1.4) in SNS (show SCN10A Antibodies)-gp130 (show LRPPRC Antibodies)(-/-) nociceptors.
The experiments here demonstrate that Kv4.2 (show KCND2 Antibodies), Kv4.3 (show KCND3 Antibodies) and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.
Kv1.4- and Kv4.2 (show KCND2 Antibodies)-encoded I(A) channels regulate the intrinsic excitability of SCN (show SRI Antibodies) neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN (show SRI Antibodies) neuron firing and locomotor behavior.
This study demonistrated that Kcna4 gene expression in mouse dorsal raphe nucleus
Targeted deletion of Kv1.4 alpha-subunit (show POLG Antibodies) (along with Kv4.2 (show KCND2 Antibodies) and Kv4.3 (show KCND3 Antibodies)) demonstrates that individual alpha-subunits encode for the I(A) current in cortical pyramidal neurons.
PSD-95 (show DLG4 Antibodies) increased the amount of Kv1.4, but not Kv4.2 (show KCND2 Antibodies), in lipid rafts.
Data indicate that Kv1.4 expression is mediated through a complex interplay between many distinct RNA regions.
Pituitary adenylate cyclase activating polypeptide (show ADCYAP1 Antibodies) reduces kv1.4 epression in olfactory bulb.
In experimental autoimmune encephalomyelitis, Kv1.4 immunoreactivity was detected in or around lesions already during disease onset with a peak early and a subsequent decrease in the late phase of the disease.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.
Kv1.4 voltage-gated potassium channel
, potassium channel alpha subunit Kv1.4
, potassium voltage-gated channel, shaker-related subfamily, member 4
, potassium channel Shaker alpha subunit variant cKv1.4(m)
, Kv1.4 potassium channel
, potassium voltage gated channel, shaker related subfamily, member 4
, potassium voltage-gated channel subfamily A member 4
, voltage-gated potassium channel subunit Kv1.4
, cardiac potassium channel
, fetal skeletal muscle potassium channel
, potassium channel 2
, rapidly inactivating potassium channel
, shaker-related potassium channel Kv1.4
, type A potassium channel
, voltage-gated K(+) channel HuKII
, voltage-gated potassium channel HBK4
, voltage-gated potassium channel HK1
, potassium voltage-gated channel, shaker-related subfamily, memeber 4