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PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Additionally we are shipping PBX1 Antibodies (67) and PBX1 Kits (2) and many more products for this protein.
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Both histone H3 (show HIST3H3 Proteins) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.
Thus, PTBP1 (show PTBP1 Proteins) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.
Pbx1-dependent control of VMC (show PLXNA3 Proteins) differentiation kinetics underlies gross renal vascular patterning.
Results thus show how Pbx1 controls Fgf10 (show FGF10 Proteins) in the developing lung.
Prep1 and Meis1 (show MEIS1 Proteins) competition for Pbx1 binding regulates protein stability and tumorigenesis.
These results demonstrate a role for Pbx1 in restraining myeloid maturation while maintaining lymphoid potential to appropriately regulate progenitor reservoirs.
The Systemic Lupus Erythematosus-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.
Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse.
In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 (show NTN1 Proteins) receptor, deleted in colon cancer, is down-regulated.
results indicate that E2A (show TCF3 Proteins)-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A (show TCF3 Proteins) fusion genes to develop B-lineage ALL
Review of the role of the E2A (show TCF3 Proteins)-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
This study thus suggests that RNF6 (show RNF6 Proteins) overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 (show RNF6 Proteins) axis can be developed as a novel therapeutic target of leukemia.
Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha (show ESR1 Proteins)-positive breast cancers.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3 (show TCF3 Proteins)-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) subtype
This association study successfully identified two susceptibility Single Nucleotide Polymorphisms, (WNT9B (show WNT9B Proteins) and PBX1) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk, both separately and interactively.
PBX1 promotes frontal cortex patterning by repressing genes that promote dorsocaudal fate.
When intensive chemotherapy was used, the TCF3 (show TCF3 Proteins)-PBX1 was associated with a favorable outcome in childhood pre-B ALL.
Induction of PBX1 expression was associated with 13-cisRA responsiveness in neuroblastoma (show ARHGEF16 Proteins).
In this study, we showed that TCF3 (show TCF3 Proteins)-PBX1 positive pediatric BCP (show OPN1SW Proteins)-ALL patients treated according to the JACLS ALL02 and CCLSG ALL2004 protocol had favorable outcomes
These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
homeobox protein PBX1
, pre B-cell leukemia transcription factor 1
, pre-B-cell leukemia transcription factor 1
, homeobox protein PRL
, Homeobox protein pbx1
, pre-B-cell leukemia transcription factor 1b