Pre-B-Cell Leukemia Homeobox Protein 1 Proteins (PBX1)

PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Additionally we are shipping PBX1 Antibodies (72) and PBX1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBX1 5087 P40424
PBX1 18514 P41778
Rat PBX1 PBX1 304947  
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Top PBX1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,942.50
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,942.50
Details

PBX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Interaction Partners

Human Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. This is the first time the protein partners of either E2A (show TCF3 Proteins)-PBX1 or HOXA9 (show HOXA9 Proteins) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (show HOXA9 Proteins) might indicate a novel function for HOX (show MSH2 Proteins) proteins independent of their transcriptional activity.

  2. these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.

  3. the PBX1 binding motif at its promoter acted to positively regulate STAT3 (show STAT3 Proteins) transcription.

  4. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 Proteins)(+) T cell effector function

  5. Notably, PBX1 and NFE2L1 (show NFE2L1 Proteins) levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 (show NFE2L1 Proteins) levels increases damage by oxidative stress in human midbrain cells.

  6. PBX1 overexpression in MCF10A cells up-regulated most LiMe (show LIME1 Proteins) genes.

  7. results indicate that E2A (show TCF3 Proteins)-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A (show TCF3 Proteins) fusion genes to develop B-lineage ALL

  8. Review of the role of the E2A (show TCF3 Proteins)-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.

  9. This study thus suggests that RNF6 (show RNF6 Proteins) overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 (show RNF6 Proteins) axis can be developed as a novel therapeutic target of leukemia.

  10. Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha (show ESR1 Proteins)-positive breast cancers.

Zebrafish Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. findings suggest that pbx1 may be required during the late stage of swim bladder development

Mouse (Murine) Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. MEIS2 (show MEIS2 Proteins) associates with chromatin-bound PBX1, recruits PARP1/ARTD1 (show PARP1 Proteins), and initiates PARP1 (show PARP1 Proteins)-mediated eviction of H1 from the chromatin fiber.

  2. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.

  3. PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2 (show MEIS2 Proteins).

  4. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 Proteins)(+) T cell effector function

  5. FLT3 (show FLT3 Proteins)-ITD is capable of inhibiting FLT3 (show FLT3 Proteins)-ITD+ cell proliferation through the p21/Pbx1 axis

  6. Both histone H3 (show HIST3H3 Proteins) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.

  7. Thus, PTBP1 (show PTBP1 Proteins) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.

  8. this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.

  9. Pbx1-dependent control of VMC (show PLXNA3 Proteins) differentiation kinetics underlies gross renal vascular patterning.

  10. Results thus show how Pbx1 controls Fgf10 (show FGF10 Proteins) in the developing lung.

Xenopus laevis Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.

PBX1 Protein Profile

Protein Summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PBX1

  • pre-B-cell leukemia homeobox 1 (PBX1)
  • pre-B-cell leukemia transcription factor 1a (pbx1a)
  • pre B cell leukemia homeobox 1 (Pbx1)
  • pre-B-cell leukemia homeobox 1 (Pbx1)
  • pre-B-cell leukemia homeobox 1 (pbx1)
  • 2310056B04Rik protein
  • AI848790 protein
  • AU015730 protein
  • D230003C07Rik protein
  • fi29e01 protein
  • Pbx-1 protein
  • PBX1A protein
  • Pbx1b protein
  • wu:fi29e01 protein
  • Xpbx1 protein
  • Xpbx1b protein
  • zgc:55265 protein

Protein level used designations for PBX1

homeobox protein PBX1 , homeobox protein PRL , pre-B-cell leukemia transcription factor 1 , pre-B-cell leukemia transcription factor 1b , pre B-cell leukemia transcription factor 1 , Homeobox protein pbx1

GENE ID SPECIES
5087 Homo sapiens
58138 Danio rerio
18514 Mus musculus
304947 Rattus norvegicus
395505 Gallus gallus
488669 Canis lupus familiaris
540688 Bos taurus
399184 Xenopus laevis
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