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PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Additionally we are shipping PBX1 Antibodies (72) and PBX1 Kits (2) and many more products for this protein.
Showing 6 out of 6 products:
This is the first time the protein partners of either E2A (show TCF3 Proteins)-PBX1 or HOXA9 (show HOXA9 Proteins) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (show HOXA9 Proteins) might indicate a novel function for HOX (show MSH2 Proteins) proteins independent of their transcriptional activity.
these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.
the PBX1 binding motif at its promoter acted to positively regulate STAT3 (show STAT3 Proteins) transcription.
Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 Proteins)(+) T cell effector function
Notably, PBX1 and NFE2L1 (show NFE2L1 Proteins) levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 (show NFE2L1 Proteins) levels increases damage by oxidative stress in human midbrain cells.
PBX1 overexpression in MCF10A cells up-regulated most LiMe (show LIME1 Proteins) genes.
results indicate that E2A (show TCF3 Proteins)-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A (show TCF3 Proteins) fusion genes to develop B-lineage ALL
Review of the role of the E2A (show TCF3 Proteins)-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
This study thus suggests that RNF6 (show RNF6 Proteins) overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 (show RNF6 Proteins) axis can be developed as a novel therapeutic target of leukemia.
Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha (show ESR1 Proteins)-positive breast cancers.
findings suggest that pbx1 may be required during the late stage of swim bladder development
MEIS2 (show MEIS2 Proteins) associates with chromatin-bound PBX1, recruits PARP1/ARTD1 (show PARP1 Proteins), and initiates PARP1 (show PARP1 Proteins)-mediated eviction of H1 from the chromatin fiber.
Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.
PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2 (show MEIS2 Proteins).
FLT3 (show FLT3 Proteins)-ITD is capable of inhibiting FLT3 (show FLT3 Proteins)-ITD+ cell proliferation through the p21/Pbx1 axis
Both histone H3 (show HIST3H3 Proteins) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.
Thus, PTBP1 (show PTBP1 Proteins) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.
Pbx1-dependent control of VMC (show PLXNA3 Proteins) differentiation kinetics underlies gross renal vascular patterning.
Results thus show how Pbx1 controls Fgf10 (show FGF10 Proteins) in the developing lung.
These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
homeobox protein PBX1
, homeobox protein PRL
, pre-B-cell leukemia transcription factor 1
, pre-B-cell leukemia transcription factor 1b
, pre B-cell leukemia transcription factor 1
, Homeobox protein pbx1