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PRICKLE2 encodes a homolog of Drosophila prickle. Additionally we are shipping and many more products for this protein.
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2 autism-spectrum-disorder patients had distinct, paternally inherited, heterozygous, non-synonymous PRICKLE2 variants (p.E8Q and p.V153I) shared by their affected siblings. These variants had deficits in morphological and electrophysiological assays.
MINK1 (show MINK1 Antibodies) interacts with and phosphorylates PRICKLE1 (show PRICKLE1 Antibodies) and PRICKLE2.
PRICKLE1 (show PRICKLE1 Antibodies) and PRICKLE2 mRNAs were expressed together in brain, eye and testis.
Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP (show BMP1 Antibodies) factors by electroporation revealed that Vangl1 (show Vangl1 Antibodies), Vangl2 (show VANGL2 Antibodies) and Prickle2 are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 (show VANGL2 Antibodies) asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model
The results of this study demonstrated that Prickle2 is required for normal ependymal motile cilia development and function.
Prickle2 disruption causes behavioral abnormalities like altered social interaction, learning abnormalities and behavioral inflexibility. In mouse hippocampal neurons, it reduced dendrite branching, synapse number and postsynaptic density size.
The cell polarity phenotype was efficiently rescued by nuclear but not cytoplasmic Prickle2, demonstrating the nuclear localization of Prickle2 is critical for its function.
Prickle1 (show PRICKLE1 Antibodies) and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1 (show DVL1 Antibodies)-dependent mechanism
The prickle2 protein is a novel PSD (show PSD Antibodies) protein that interacts with PSD-95 (show DLG4 Antibodies) and NMDA receptors through complex formations in the brain.
both Prickle1 (show PRICKLE1 Antibodies) and Prickle2 promote neurite-like process formation of C1300 neuroblastoma (show ARHGEF16 Antibodies) cells via the Dishevelled (show DVL2 Antibodies) dependent pathway
Putative planar cell polarity protein prickle-like 2 is distributed in crescents on the medial sides of vestibular epithelial cells before the morphological polarization of hair cells.
mouse Prickle1 (show PRICKLE1 Antibodies) and Prickle2 possibly regulate positive neurite formation during brain development
Zebrafish pk2 modulates convergence and extension movements in gastrulation, and retinal neurogenesis.
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5.
prickle-like protein 2
, prickle-like 2