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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Antibodies (234) and PDCD4 Kits (13) and many more products for this protein.
Showing 10 out of 12 products:
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) Pathway.
Study found that miR-16 (show GDE1 Proteins) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (show MLXIP Proteins)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells
we demonstrate that miR (show MLXIP Proteins)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.
Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis
miR (show MLXIP Proteins)-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3 (show CASP3 Proteins)/8 fragments in the condition of renal IRI
sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 (show AKT1 Proteins) and/or S6K1 (show RPS6KB1 Proteins) activities in RAW 264.7 cells
miR (show MLXIP Proteins)-21 can confer drug resistance to 5-FU in pancreatic cancer cells by regulating the expression of tumor suppressor genes, as the target genes of miR (show MLXIP Proteins)-21, PTEN and PDCD4 can rescue 5-FU sensitivity and the phenotypic characteristics disrupted by miR (show MLXIP Proteins)-21.
In HeLa cells, phosphorylation of HuR (show ELAVL1 Proteins) by ERK8 (show MAPK15 Proteins) prevents it from binding to PDCD4 mRNA and allows miR (show MLXIP Proteins)-21-mediated degradation of PDCD4.
miR (show MLXIP Proteins)-183 maybe functions as an oncogene (show RAB1A Proteins) by regulating gastric cancer cell proliferation, apoptosis and metastasis and the oncogenic effect of miR (show MLXIP Proteins)-183 may relate the direct targeting PDCD4
PDCD4 inhibits cell growth through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling in non-small cell lung cancer.
This study describes the regulation of PDCD4 specifically in tonsil SCC (show CYP11A1 Proteins) by miR (show MLXIP Proteins)-499 and miR (show MLXIP Proteins)-21 and has documented the loss of PDCD4 in oropharyngeal squamous cell carcinoma
Unprecedentedly, HuR (show ELAVL1 Proteins) was also found to bind to miR (show MLXIP Proteins)-21 directly, preventing its interaction with the PDCD4 3'-UTR, thereby preventing the translation repression of PDCD4.
miR (show MLXIP Proteins)-21 has a role in upregulating PTEN, RECK (show RECK Proteins) and PDCD4 in glioma
PDGF (show PDGFA Proteins)-BB stimulates cell proliferation through microRNA-21-mediated PDCD4 down-regulation, leading to the development of TAO.
Results indicated that PDCD4 may be a novel candidate of tumor suppressor gene in hepatocellular carcinoma and that promoter hypermethylation is an important mechanism for its downregulation and a good predictor of survival.
These findings suggest that miR (show MLXIP Proteins)-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4
, programmed cell death protein 4-like
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, neoplastic transformation inhibitor protein
, nuclear antigen H731
, protein 197/15a
, protein I11/6