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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Antibodies (233) and PDCD4 Kits (13) and many more products for this protein.
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PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (show MLXIP Proteins)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells
we demonstrate that miR (show MLXIP Proteins)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.
Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis
miR (show MLXIP Proteins)-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3 (show CASP3 Proteins)/8 fragments in the condition of renal IRI
sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 (show AKT1 Proteins) and/or S6K1 (show RPS6KB1 Proteins) activities in RAW 264.7 cells
these findings support the existence of a microRNA-21-responsive PDCD4/caspase-3 (show CASP3 Proteins) pathway in the pulmonary tissues that when active serves to promote endothelial apoptosis in vitro and pulmonary hypertension in vivo.
we demonstrated that the miR (show MLXIP Proteins)-21-PDCD4 signaling was involved in the cellular responses to UVB in a mouse epidermal cell line
during bacterial pneumonia IFNlambda promotes inflammation by inhibiting miR (show MLXIP Proteins)-21 regulation of PDCD4.
PDCD4 inhibits cell growth through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling in non-small cell lung cancer.
This study describes the regulation of PDCD4 specifically in tonsil SCC (show CYP11A1 Proteins) by miR (show MLXIP Proteins)-499 and miR (show MLXIP Proteins)-21 and has documented the loss of PDCD4 in oropharyngeal squamous cell carcinoma
Unprecedentedly, HuR (show ELAVL1 Proteins) was also found to bind to miR (show MLXIP Proteins)-21 directly, preventing its interaction with the PDCD4 3'-UTR, thereby preventing the translation repression of PDCD4.
miR (show MLXIP Proteins)-21 has a role in upregulating PTEN, RECK (show RECK Proteins) and PDCD4 in glioma
PDGF (show PDGFA Proteins)-BB stimulates cell proliferation through microRNA-21-mediated PDCD4 down-regulation, leading to the development of TAO.
Results indicated that PDCD4 may be a novel candidate of tumor suppressor gene in hepatocellular carcinoma and that promoter hypermethylation is an important mechanism for its downregulation and a good predictor of survival.
These findings suggest that miR (show MLXIP Proteins)-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future.
We propose that SRSF3 (show SRSF3 Proteins) could act as a coordinator of the expression of PDCD4 protein via two mechanisms on two alternatively spliced mRNA isoforms.
Low PDCD4 increases osteosarcoma cells resistance to apoptosis.
These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 (show IL6 Proteins), miR (show MLXIP Proteins)-21, and PDCD4.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4
, programmed cell death protein 4-like
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, neoplastic transformation inhibitor protein
, nuclear antigen H731
, protein 197/15a
, protein I11/6