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Prokineticin 2 Proteins (PROK2)

PROK2 encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. Additionally we are shipping Prokineticin 2 Antibodies (53) and Prokineticin 2 Kits (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROK2 192206 Q8R413
PROK2 50501 Q9QXU7
PROK2 60675 Q9HC23
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Top Prokineticin 2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$745.50
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,115.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,178.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 9 to 11 Days
$651.20
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

PROK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Mouse (Murine)

Human ,
,

More Proteins for Prokineticin 2 (PROK2) Interaction Partners

Zebrafish Prokineticin 2 (PROK2) interaction partners

  1. In adult zebrafish, PROK2 may play a role in both constitutive and injury-induced neurogenesis during telencephalon regeneration.

Cow (Bovine) Prokineticin 2 (PROK2) interaction partners

  1. EG-VEGF/PK1 and Bv8/PK2 thus represent new regulatory peptides acting as autocrine mitogens for endocrine cells

Mouse (Murine) Prokineticin 2 (PROK2) interaction partners

  1. PROK2 plays a role in cerebral amyloidosis and that PROK2 antagonists may represent a new approach for ameliorating the defining pathology of AD.

  2. Data show that the prokineticins and their receptors PROK2, PKR1 (show PROKR1 Proteins) and PKR2 (show PROKR2 Proteins) contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.

  3. These findings suggest that PROK2 plays a crucial role in neuropathic pain and might represent a novel target of treatment for this disease.

  4. Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals

  5. PK2 plays an important role in energy intake and expenditure.

  6. Induction of Bv8 expression by granulocyte colony-stimulating factor (show CSF3 Proteins) in CD11b (show ITGAM Proteins)+Gr1 (show GSR Proteins)+ cells: key role of Stat3 (show STAT3 Proteins) signaling.

  7. Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors.

  8. Intracerebroventricular administration of PK2 affects regulation of food intake.

  9. Bv8 and EG-VEGF (show Prok1 Proteins), along with other factors such as VEGF-A (show VEGFA Proteins), may maintain the integrity and also regulate proliferation of the blood vessels in the testis

  10. Light inducibility of PK2 suggests that in addition to its role in clock-driven rhythms of locomotor behaviour, PK2 may also participate in the photic entrainment of circadian locomotor rhythms.

Human Prokineticin 2 (PROK2) interaction partners

  1. Prokineticin-2 is correlated with various cardiometabolic risk factors.

  2. Data suggest that prokineticins (PROK1 (show Prok1 Proteins) and PROK2) and prokineticin receptors (PROKR1 (show PROKR1 Proteins) and PROKR2 (show PROKR2 Proteins)) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]

  3. Suggest PROK2 as an angiogenic growth factor in colorectal cancer.

  4. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR (show GNRHR Proteins) gene had been previously described, suggesting the possibility of a digenic inheritance

  5. PROK2 significantly increased in human fetal ovary across gestation.

  6. EG-VEGF (show Prok1 Proteins), BV8, and PROKR2 (show PROKR2 Proteins) gene expression is approximately five, four, and two times higher in cystic fibrosis (show S100A8 Proteins) lungs compared with controls.

  7. No abnormalities were found in the patient group for the PROKR2 (show PROKR2 Proteins) and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes

  8. PROK2 signaling in humans is not required for central circadian pacemaker function.

  9. A novel role of BV8 in promoting oncogenesis intrinsic to malignant cells of myeloid origin.

  10. We could not implicate the ligand PROK2 in congenital hypopituitarism and septo-optic dysplasia.

Prokineticin 2 (PROK2) Protein Profile

Protein Summary

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Prokineticin 2 Proteins (PROK2)

  • prokineticin 2 (PROK2)
  • prokineticin 2 (prok2)
  • prokineticin 2 (Prok2)
  • BV8 protein
  • HH4 protein
  • KAL4 protein
  • MIT1 protein
  • PK2 protein
  • Prok1 protein
  • PROK2 protein

Protein level used designations for Prokineticin 2 Proteins (PROK2)

prokineticin 2 , prokineticin-2 , PK2 , homolog of mouse Bv8 (Bombina variegata 8 kDa) , homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 , prokineticin 2 beta , Bombina variegata 8 kD protein , Bombina variegata 8kDa protein , Bv 8 homolog (Bombina variegata) , prokineticin 1 , protein Bv8 homolog

GENE ID SPECIES
694450 Macaca mulatta
736902 Pan troglodytes
100006398 Danio rerio
100037158 Xenopus laevis
387602 Bos taurus
192206 Rattus norvegicus
50501 Mus musculus
60675 Homo sapiens
100728998 Cavia porcellus
610873 Canis lupus familiaris
771674 Gallus gallus
101104864 Ovis aries
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