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Prolyl 4-Hydroxylase, alpha Polypeptide I Proteins (P4HA1)

P4HA1 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. Additionally we are shipping P4HA1 Antibodies (55) and P4HA1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P4HA1 18451 Q60715
P4HA1 5033 P13674
P4HA1 64475 P54001
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Top P4HA1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,470.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

P4HA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) Interaction Partners

Mouse (Murine) Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) interaction partners

  1. IL-6 (show IL6 Proteins) destabilizes atherosclerotic plaques by downregulating P4Halpha1 via an RAF-MEK1/2-ERK1/2 MAPK and c-Jun pathway.

  2. C-P4H alpha(I) and alpha(II (show GSTA3 Proteins)) mRNA levels were increased in hypoxic mouse chondrocytes in a manner dependent on HIF-1a (show HIF1A Proteins).

Human Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) interaction partners

  1. Thus, we conclude that miR (show MLXIP Proteins)-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA.

  2. Studies indicate P4HA1 copy number gain in a subset of metastatic prostate tumors and its expression is also regulated by microRNA-124.

  3. Overexpression of miR (show MLXIP Proteins)-122 markedly attenuated the expression of P4HA1 via targeting a binding site located at 3'-UTR of P4HA1 mRNA

  4. Hypoxia-inducible factor 1 (HIF-1 (show HIF1A Proteins)) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2 (show P4HA2 Proteins), and PLOD2 (show PLOD2 Proteins) expression in fibroblasts.

  5. IL-6 (show IL6 Proteins) significantly downregulated P4Halpha1 expression in aortic smooth muscle cells

  6. analysis of the 2-His-1 (show HTN1 Proteins)-Asp (show ASIP Proteins) active-site motif in prolyl 4-hydroxylase

  7. Collagen prolyl 4-hydroxylase-alpha (I)mRNA is stabilized by interation of RNA-binding proteins hnRNP-A2/B1 with a U(16) element within the 3'-UTR

  8. Results suggest that the alteration of translational efficiency by nucleolin (show NCL Proteins), which occurs through a hypoxia inducible factor independent pathway, is an important step in collagen prolyl 4-hydroxylase-alpha(I) regulation under hypoxia.

  9. HIF-P4H, HIF-1alpha (show HIF1A Proteins) and HIF-2alpha (show EPAS1 Proteins) are effective oxygen sensors

P4HA1 Protein Profile

Protein Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with P4HA1

  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ000975)
  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ017131)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03346)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03347)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_15957)
  • prolyl 4-hydroxylase, alpha polypeptide I (P4HA1)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1)
  • prolyl 4-hydroxylase, alpha polypeptide I (P4ha1)
  • AL022634 protein
  • P4ha protein
  • PHalphaI protein

Protein level used designations for P4HA1

prolyl 4-hydroxylase subunit alpha-1 , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I , prolyl 4-hydroxylase alpha subunit , prolyl 4-hydroxylase, alpha I subunit , 4-PH alpha-1 , procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 , C-P4Halpha(I) , collagen prolyl 4-hydroxylase alpha(I) , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

GENE ID SPECIES
6031971 Culex quinquefasciatus
6051272 Culex quinquefasciatus
10909085 Trichinella spiralis
10909086 Trichinella spiralis
10909998 Trichinella spiralis
100037299 Sus scrofa
450891 Pan troglodytes
18451 Mus musculus
5033 Homo sapiens
479242 Canis lupus familiaris
64475 Rattus norvegicus
518288 Bos taurus
423704 Gallus gallus
100172658 Pongo abelii
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