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Prolyl 4-Hydroxylase, alpha Polypeptide II Proteins (P4HA2)

P4HA2 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. Additionally we are shipping P4HA2 Antibodies (21) and P4HA2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P4HA2 18452 Q60716
P4HA2 8974 O15460
Rat P4HA2 P4HA2 360526  
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Top P4HA2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

P4HA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Prolyl 4-Hydroxylase, alpha Polypeptide II (P4HA2) Interaction Partners

Mouse (Murine) Prolyl 4-Hydroxylase, alpha Polypeptide II (P4HA2) interaction partners

  1. C-P4H alpha(I) and alpha(II (show GSTA3 Proteins)) mRNA levels were increased in hypoxic mouse chondrocytes in a manner dependent on HIF-1a (show HIF1A Proteins).

  2. HIF-1 (show HIF1A Proteins) activation following infusion of siRNA to P4HA2 plays a key role in modulating I/R-associated cardiac inflammatory responses.

Human Prolyl 4-Hydroxylase, alpha Polypeptide II (P4HA2) interaction partners

  1. P4HA2 was identified as a novel causative gene for nonsyndromic high myopia.

  2. Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression.

  3. Hypoxia-inducible factor 1 (HIF-1 (show HIF1A Proteins)) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1 (show P4HA1 Proteins), P4HA2, and PLOD2 (show PLOD2 Proteins) expression in fibroblasts.

  4. P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues.

  5. Overexpression of PRDX4 (show PRDX4 Proteins) and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma

  6. HIF-P4H, HIF-1alpha (show HIF1A Proteins) and HIF-2alpha (show EPAS1 Proteins) are effective oxygen sensors

  7. results show that p53 (show TP53 Proteins) transcriptionally activates the alpha(II (show GSTA3 Proteins)) collagen prolyl-4-hydroxylase [alpha(II (show GSTA3 Proteins))PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18

P4HA2 Protein Profile

Protein Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with P4HA2

  • prolyl 4-hydroxylase, alpha polypeptide II (P4HA2)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide (P4ha2)
  • prolyl 4-hydroxylase, alpha polypeptide II (P4ha2)
  • AA407196 protein
  • C76437 protein
  • P4hl protein

Protein level used designations for P4HA2

prolyl 4-hydroxylase subunit alpha-2 , procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide II, isoform 1 , prolyl 4-hydroxylase, alpha II subunit , prolyl 4-hydroxylase, alpha polypeptide II , prolyl 4-hydroxylase subunit alpha-2-like , 4-PH alpha-2 , Prolyl 4-hydroxylase alpha IIa subunit , procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 , 4-PH alpha 2 , C-P4Halpha(II) , collagen prolyl 4-hydroxylase alpha(II) , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide , prolyl 4-hydroxylase alpha-2 subunit

GENE ID SPECIES
100137538 Papio anubis
100328721 Oryctolagus cuniculus
100448172 Pongo abelii
100480972 Ailuropoda melanoleuca
100593863 Nomascus leucogenys
100623801 Sus scrofa
18452 Mus musculus
8974 Homo sapiens
360526 Rattus norvegicus
416326 Gallus gallus
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