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The protein encoded by PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. Additionally we are shipping Prolylcarboxypeptidase Kits (41) and Prolylcarboxypeptidase Proteins (12) and many more products for this protein.
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Data show that the KKN1 fragment generated by BMP1 (show BMP1 Antibodies)-cleavage of WFIKKN1 (show WFIKKN1 Antibodies) protein contributes most significantly to the observed enhancer activity.
For the first time, PRCP is identified as an apelin (show APLN Antibodies)-cleaving enzyme.
a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 (show BMP1 Antibodies) in the EGF (show EGF Antibodies) domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
BMP-1 (show BMP1 Antibodies) accelerates the connective tissue growth factor (show CTGF Antibodies) production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 (show BMP1 Antibodies) which potentially enhances bone-like reparative dentin formation.
Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.
study thus highlights the severe and progressive nature of BMP1 (show BMP1 Antibodies)-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM (show MMRN1 Antibodies) organization.
Data indicate that BMP-1 (show BMP1 Antibodies) can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review]
The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome
Two novel variants in the BMP1 (show BMP1 Antibodies) gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta (show COL1A2 Antibodies).
Frequent bone fracture in children is cause by BMP1 (show BMP1 Antibodies)-1 deficiency.
This study demonistrated that PRCP gene is broadly expressed in the brain.
PRCP regulates cell growth, angiogenesis, and the response to vascular injury
ACE2 (show ACE2 Antibodies) metabolizes ANG II (show AGT Antibodies) in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet
analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin (show LEP Antibodies) levels and increased energy expenditure were also found.
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, mammalian tolloid protein
, procollagen C-endopeptidase
, procollagen C-proteinase
, lysosomal Pro-X carboxypeptidase
, proline carboxypeptidase
, angiotensinase C
, lysosomal carboxypeptidase C
, prolylcarboxypeptidase isoform 1 preproprotein