PRCP antibody (N-Term)

Catalog No. ABIN657308

The Rabbit Polyclonal anti-PRCP antibody is suitable to detect PRCP in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for PRCP antibody (N-Term) (ABIN657308)

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRCP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB32742

Product Details anti-PRCP Antibody

Binding Specificity: AA 114-143, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PRCP

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Alternative Name: PRCP

Background: The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH , but the enzyme activity is retained with some substrates at neutral pH . This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].

Molecular Weight: 55800

NCBI Accession: NP_005031, NP_955450

UniProt: P42785