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Prospero Homeobox 1 Proteins (PROX1)

The protein encoded by PROX1 is a member of the homeobox transcription factor family. Additionally we are shipping Prospero Homeobox 1 Antibodies (167) and Prospero Homeobox 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROX1 5629 Q92786
Rat PROX1 PROX1 305066  
PROX1 19130 P48437
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Top Prospero Homeobox 1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 5 Days

PROX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Prospero Homeobox 1 (PROX1) Interaction Partners

Human Prospero Homeobox 1 (PROX1) interaction partners

  1. High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.

  2. Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells.

  3. PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells.

  4. Findings demonstrate that NOTCH (show NOTCH1 Proteins)-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma.

  5. These results suggest that the hepatic functions of the human iPS (show SLC27A4 Proteins)-HLCs (show HLCS Proteins) could be enhanced by ATF5 (show ATF5 Proteins), c/EBPalpha (show CEBPA Proteins), and PROX1 transduction.

  6. In primary lymphatic endothelial cells (HDLEC), miR (show MLXIP Proteins)-466 mimic transfection suppressed Prox1 mRNA and protein expression. HDLEC transfected with the miR (show MLXIP Proteins)-466 mimic suppressed tube formation as compared to the scrambled control.

  7. Increase in PROX1 expression renders HCC (show FAM126A Proteins) cells more resistant to sorafenib treatment.

  8. Our results indicate that immunohistochemical detection of PROX1 correlates with a more malignant phenotype in rectal neuroendocrine tumors

  9. PROX1 target genes and show that repression of a pro-apoptotic member of the BCL2 (show BCL2 Proteins) family, BCL2L15, is important for survival of PROX1(+) cells under metabolic stress.

  10. Prox1 regulates PDPN (show PDPN Proteins) expression at the transcriptional level in the lymphatic vascular system

Mouse (Murine) Prospero Homeobox 1 (PROX1) interaction partners

  1. These results are the first demonstration that Prox1 (show C16orf35 Proteins) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (show C16orf35 Proteins) involves suppression of pathways associated with inflammatory responses and cell invasiveness.

  2. the data show that Prox1 (show C16orf35 Proteins) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.

  3. Prox1 (show C16orf35 Proteins) upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 (show C16orf35 Proteins) overexpression causes MafA (show MAFA Proteins) deficiency in beta-cells.

  4. The PROX1 (show C16orf35 Proteins)-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis

  5. suggest that Prox1 (show C16orf35 Proteins) appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality

  6. we demonstrate that Prox1 (show C16orf35 Proteins) and Asap1 (show ASAP1 Proteins) behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.

  7. Prox1 (show C16orf35 Proteins) is made in postmitotic CGE-derived cortical interneuron precursors. It is differentially required during embryonic and postnatal stages for migration, differentiation, circuit integration, and maintenance programs in subtypes of these interneurons.

  8. Sox2 (show SOX2 Proteins) was not restricted to developing taste bud cells expressing Prox1 (show C16orf35 Proteins) during circumvallate development.

  9. Expression of fluorescent Prox-1 allows functional characterization of Schlemm's canal.

  10. Prox1 (show C16orf35 Proteins) is essential for the expansion of the stem cell pool in intestinal adenomas and CRC without being critical for the normal functions of the gut (show GUSB Proteins).

Zebrafish Prospero Homeobox 1 (PROX1) interaction partners

  1. using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages

  2. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

  3. Prox1 functions as a tissue-specific coregulator of Ff1b

  4. Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (show OTOP1 Proteins)-positive hypothalamic neuronal precursors to their terminal CA phenotype

Prospero Homeobox 1 (PROX1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Prospero Homeobox 1 Proteins (PROX1)

  • prospero homeobox 1 (PROX1)
  • prospero homeobox 1 (prox1)
  • prospero-related homeobox 1 (LOC100232600)
  • prospero homeobox 1 (Prox1)
  • prospero-related homeobox 1 (Prox1)
  • prospero-related homeobox gene 1a (prox1a)
  • A230003G05Rik protein
  • LOC100232600 protein
  • prospero protein
  • prox1 protein
  • xprox1 protein
  • zgc:111888 protein

Protein level used designations for Prospero Homeobox 1 Proteins (PROX1)

prospero homeobox 1 , prospero homeobox protein 1-like , Prox 1 , prospero-related homeobox 1 , homeobox prospero-like protein PROX1 , prospero homeobox protein 1 , PROX-1 , prospero-related homeobox gene 1

100050316 Equus caballus
100357251 Oryctolagus cuniculus
100404369 Callithrix jacchus
100440139 Pongo abelii
100466739 Ailuropoda melanoleuca
100603654 Nomascus leucogenys
399348 Xenopus laevis
457728 Pan troglodytes
100134995 Xenopus (Silurana) tropicalis
100232600 Taeniopygia guttata
100567246 Anolis carolinensis
5629 Homo sapiens
305066 Rattus norvegicus
395802 Gallus gallus
490291 Canis lupus familiaris
100169702 Sus scrofa
515324 Bos taurus
19130 Mus musculus
30679 Danio rerio
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