anti-Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Antibodies

The protein encoded by PTGER4 is a member of the G-protein coupled receptor family. Additionally we are shipping PTGER4 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTGER4 5734 P35408
PTGER4 19219 P32240
PTGER4 84023 P43114
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Top anti-PTGER4 Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COLO205 cells, using PE2R4 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using PE2R4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185578 (0.1µg/ml) staining of Human Testes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated WB PTGER4 Antibody (Center) (ABIN1881704) western blot analysis in HL-60,K562 cell line and mouse brain lysates (35 µg/lane). This demonstrates the PTGER4 antibody detected the PTGER4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN251245 (0.1?g/ml) staining of Human Testes lysate (35?g protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: PTGER4/EP4 Antibody [NBP1-84833] - Staining of human small intestine shows strong cytoplasmic and membranous positivity in glandular cells. Western Blot: PTGER4/EP4 Antibody [NBP1-84833] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Cow Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: PTGER4/EP4 Antibody [NLS3890] - Analysis of anti-PTGER4 / EP4 antibody with human colon, ganglion at 2 ug/ml. 0.05 mL Log in to see 10 to 13 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p) Immunocytochemistry/Immunofluorescence: PTGER4/EP4 Antibody [NLS3898] - Analysis of anti-PTGER4 / EP4 antibody with transfection control. Immunocytochemistry/Immunofluorescence: PTGER4/EP4 Antibody [NLS3898] - Analysis of anti-PTGER4 / EP4 antibody with transfected cells expressing Prostaglandin E Receptor EP4 at 8 ug/ml. 0.05 mL Log in to see 10 to 13 Days
$447.56
Details
Dog Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IF, IHC (p) Cells expressing target protein - immunostained with target antibody 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific cells using EP4 Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details

PTGER4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,
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Rat (Rattus) ,


Top referenced anti-PTGER4 Antibodies

  1. Human Polyclonal PTGER4 Primary Antibody for WB - ABIN1881704 : Bastien, Sawyer, Grygorczyk, Metters, Adam: Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. in The Journal of biological chemistry 1994 (PubMed)
    Show all 4 references for 1881704

  2. Human Polyclonal PTGER4 Primary Antibody for ELISA, WB - ABIN251245 : Parida, Parekh, Dey, Ghosh, Mandal: Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model. in Cancer biology & therapy 2015 (PubMed)
    Show all 3 references for 251245

  3. Human Polyclonal PTGER4 Primary Antibody for ICC, IF - ABIN4348399 : Prijatelj, Celhar, Mlinaric-Rascan: Prostaglandin EP4 receptor enhances BCR-induced apoptosis of immature B cells. in Prostaglandins & other lipid mediators 2011 (PubMed)
    Show all 2 references for 4348399

  4. Cow (Bovine) Polyclonal PTGER4 Primary Antibody for IHC (p) - ABIN4348398 : Oll, Baumann, Behbahani, von Ruecker, Müller, Ellinger: Identification of prostaglandin receptors in human ureters. in BMC urology 2013 (PubMed)

  5. Human Polyclonal PTGER4 Primary Antibody for IF, ELISA - ABIN1535602 : Foord, Marks, Stolz, Bufflier, Fraser, Lee: The structure of the prostaglandin EP4 receptor gene and related pseudogenes. in Genomics 1996 (PubMed)

  6. Human Polyclonal PTGER4 Primary Antibody for ELISA, WB - ABIN185578 : Echeverria, Clerman, Doré: Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure. in The European journal of neuroscience 2005 (PubMed)

More Antibodies against PTGER4 Interaction Partners

Zebrafish Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Lkt/ABCC4 (show ABCC4 Antibodies)-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor (show GPBAR1 Antibodies), EP4, to upregulate cAMP synthesis and increase anterograde intraflagellar transport, thereby promoting ciliogenesis.

  2. Ep4a, a PGE2 receptor isoform of EP4, is involved in lymphoid precursor development in zebrafish.

Human Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis.

  2. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM (show MMRN1 Antibodies), as well as the invasion of breast cancer cells in in vitro models.

  3. EP4 expression can promote the development of resistance to aromatase (show CYP19A1 Antibodies) inhibitor therapy for breast cancer

  4. Findings suggest SUMO-1 (show SUMO1 Antibodies) protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers.

  5. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR (show EGFR Antibodies) interactive signaling.

  6. The cross-talk between SP1 (show PSG1 Antibodies) and p65 (show GORASP1 Antibodies), and the positive feedback regulatory loop of PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling by EP4 contribute to the overall responses of solamargine in this process

  7. The PTGER4 gene is a candidate risk factor for radiological progression in rheumatoid arthritis

  8. IP and EP4 receptors have a role in prostanoid regulation of angiogeneis

  9. miRNA 526b is a COX-2 (show COX2 Antibodies) upregulated, oncogenic miRNA promoting stem-like cells, the expression of which follows EP4 receptor-mediated signaling.

  10. Altered inhibitory function of the EP4R in eosinophils and monocytes from aspirin-intolerant patients

Mouse (Murine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Myeloid cell Ptger4 modulates interleukin production but not atherogenesis in type I diabetic mice.

  2. These data suggest that vascular EP4 receptors buffer the actions of AngII on renal hemodynamics and oxidative injury.

  3. these studies have demonstrated an important but unexpected role for macrophage COX-2 (show COX2 Antibodies)/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 (show COX2 Antibodies) expression in intrinsic renal cells.

  4. data demonstrate that endogenous PGE2, EP2 (show SPAG11A Antibodies) receptors, and EPAC (show RAPGEF3 Antibodies) are prerequisites for maximal LPS (show TLR4 Antibodies)-induced IL-33 (show IL33 Antibodies) expression and that exogenous PGE2 can amplify IL-33 (show IL33 Antibodies) production via EP2 (show SPAG11A Antibodies) and EP4 receptors.

  5. The data presented highlight a key role for EP2 (show SPAG11A Antibodies) and EP4 receptors in microvascular leak induced by PGE2.

  6. These results suggest that Il23a (show IL23A Antibodies) expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-kappaB (show NFKB1 Antibodies) pathways and CREB (show CREB1 Antibodies) activated by CD40 (show CD40 Antibodies) stimulation.

  7. autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4 (show CD4 Antibodies)(+) T-cell activation.

  8. PGE2-mediated EP4 signaling in myeloid cells promotes tumorigenesis.

  9. the blockade of EP2 (show SPAG11A Antibodies) and EP4 promotes mouse survival after cryptococcus infection by promoting the production of cytokines via TLR4 (show TLR4 Antibodies), as well as the enhanced M1 polarization of alveolar macrophages

  10. the lean phenotype of EP4-deficient mice resulted from reduction in adipose tissue and accretion of other peripheral organs caused by impaired triglyceride clearance

Cow (Bovine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Data suggest that lysophosphatidic acid (LPA (show PLG Antibodies)) up-regulates expression of SLCO2A1 (show SLCO2A1 Antibodies) (prostaglandin [PG] transporter), PTGER2 (show PTGER2 Antibodies)/PTGER4 (PG receptors EP2 (show SPAG11A Antibodies)/EP4), and mPGES1 (show PTGES Antibodies)/cPGES (show PTGES3 Antibodies) (microsomal/cytosolic PG E synthases) in luteal cells.

  2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (show PTGER2 Antibodies) (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor (show PTGFR Antibodies)).

  3. The PGE2-mediated down-regulation of CD25 (show IL2RA Antibodies) expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 (show IL2RA Antibodies) expression on these cells.

  4. EP4 is undetectable in endometrium and myometrium during the estrous cycle

  5. Quantitative RT-PCR revealed significant higher expression of EP2 (show SPAG11A Antibodies) and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct

PTGER4 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Gene names and symbols associated with PTGER4

  • prostaglandin E receptor 4 (subtype EP4) (PTGER4) antibody
  • prostaglandin E receptor 4 (subtype EP4) a (ptger4a) antibody
  • prostaglandin E receptor 4 (subtype EP4) (ptger4) antibody
  • prostaglandin E receptor 4 (PTGER4) antibody
  • prostaglandin E receptor 4 subtype EP4 (ptger4) antibody
  • prostaglandin E receptor 4 (subtype EP4) (Ptger4) antibody
  • ep4 antibody
  • EP4R antibody
  • PGE2R-EP4 antibody
  • Ptger antibody
  • PTGER4 antibody
  • ptger4l antibody
  • Ptgerep4 antibody

Protein level used designations for PTGER4

prostaglandin E receptor 4, subtype EP4 , prostaglandin E2 receptor EP4 subtype , prostaglandin E2 receptor subtype 4 , prostaglandin E receptor 4 (subtype EP4) , ep4 , ep4a , prostaglandin E receptor 4 , prostaglandin E receptor 4 subtype EP4 , PGE receptor EP4 subtype , PGE receptor, EP4 subtype , PGE2 receptor EP4 subtype , prostanoid EP4 receptor , prostaglandin E receptor 4 (EP4 subtype) , prostaglandin E receptor EP4 subtype , prostaglandin E2 receptor type 4 , PGE receptor, subtype EP4 , prostaglandin receptor EP4 subtype , prostaglandin E2 subtype EP4 receptor

GENE ID SPECIES
427183 Gallus gallus
443222 Ovis aries
562469 Danio rerio
695220 Macaca mulatta
100145708 Xenopus (Silurana) tropicalis
100169968 Felis catus
100510774 Anolis carolinensis
5734 Homo sapiens
19219 Mus musculus
84023 Rattus norvegicus
403589 Canis lupus familiaris
282331 Bos taurus
100009081 Oryctolagus cuniculus
450195 Pan troglodytes
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