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The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Additionally we are shipping Prostaglandin E Synthase Antibodies (58) and Prostaglandin E Synthase Kits (24) and many more products for this protein.
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The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1
These findings support the value of a prognostic and predictive role for mPGES1.
Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2) and microsomal PGE (show LIPF Proteins) synthase-1 (mPGES-1) dependent pathway.
Data show that cyclooxygenase2 (COX2)overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (show EGR1 Proteins)) in colorectal cancer cell lines.
mPGES-1 is downregulated via EGR1 (show EGR1 Proteins) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes
results demonstrate that mPGES-1 is a target gene of defective mismatch repair in human colorectal cancer, with functional consequence
Altered expression of EP2 (show SPAG11B Proteins) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (show IL1B Proteins) to increase COX-2 and mPGES-1 expression, which results in low PGE2 production
High levels of intra tumoral mPGES-1 is associated with poor prognosis. mPGES-1 after chemotherapy is associated with improved outcomes.
mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor (show EGFR Proteins)-driven oncogenicity
we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 (show CXCR2 Proteins) and CXCR4 (show CXCR4 Proteins), were hypomethylated after 5-aza treatment
The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (show PGR Proteins).
mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (show LDLR Proteins) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.
Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.
Prostacyclin synthase (show PTGIS Proteins) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Gas6 (show GAS6 Proteins), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.
Vascular mPGES-1 plays a protective role in blood vessels and attenuates rupture of cerebral aneurysms.
Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.
The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL.
data suggests that an as yet unidentified prostaglanind E synthase but not mPGES-1 may couple with COX-2 to mediate increased renal PGE2 sythsesis in DN.
This study shown that mPGES-1 is expressed in the mouse brain, both in vascular endothelial cells, in several other cellular of capillary associated pericytes, astrocytes, and cells in circumventricular organs, choroid plexus, and leptomeninges.
Prostaglandin E synthase interacts with inducible heat shock protein 70 (show HSPA1A Proteins) after heat stress in bovine primary dermal fibroblast cells.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas (show FAS Proteins) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (show HSP90AA1 Proteins) (heat shock 90 kD protein 1 alpha).
PGES pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (show PTGS1 Proteins) and COX-2 (show PTGS2 Proteins) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
microsomal prostaglandin E synthase-1
, prostaglandin E synthase
, MGST1-like 1
, glutathione S-transferase 1-like 1
, microsomal glutathione S-transferase 1-like 1
, microsomal prostaglandin E synthase 1
, p53-induced apoptosis protein 12
, p53-induced gene 12 protein
, tumor protein p53 inducible protein 12