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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Additionally we are shipping PTGS1 Kits (66) and PTGS1 Proteins (10) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal PTGS1 Primary Antibody for IF (p), IHC (p) - ABIN670446
Li, Wang, Jiang, Xu, Zhang, Liu, Zhai: Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo. in International journal of molecular sciences 2011
Show all 2 Pubmed References
Human Polyclonal PTGS1 Primary Antibody for IF, IHC (p) - ABIN1882120
Helmersson, Arnlöv, Axelsson, Basu: A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. in Prostaglandins, leukotrienes, and essential fatty acids 2009
This study showed that COX-1 and COX-2 (show PTGS2 Antibodies) in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Antibodies)-1 is more prominently expressed.
COX-1 and COX-2 (show PTGS2 Antibodies) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (show PTGS2 Antibodies) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (show PTGS2 Antibodies) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (show PTGS2 Antibodies).
Immunoreactivity for COX-1 and COX-2 (show PTGS2 Antibodies) is high in equine corneal SCC (show CYP11A1 Antibodies), possibly indicating that COX (show CPOX Antibodies) plays a role in oncogenesis or progression of this tumor type at this site.
These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 (show COX1 Antibodies) activity.
Data suggest that Il4 (show IL4 Antibodies) (usually released from helper T-cells) induces Cox1 (show COX1 Antibodies) in macrophages at post-transcriptional level; activation of Ampk (show PRKAA1 Antibodies) (catalytic subunit Prkaa1 (show PRKAA1 Antibodies)) by metformin blocks Il4 (show IL4 Antibodies)-dependent induction of Cox1 (show COX1 Antibodies) and blocks macrophage polarization/activation. (Il4 (show IL4 Antibodies) = interleukin-4 (show IL4 Antibodies); Cox1 (show COX1 Antibodies) = cyclooxygenase 1; Ampk (show PRKAA1 Antibodies) = AMP-activated protein kinase (show PRKAA2 Antibodies))
Specific inhibition of PGE2 synthesis by targeting mPGES-1 (show PTGES Antibodies) may weaken host defense against bacterial infections.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Antibodies), lipoxygenase and cyclooxygenase.
role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas
Suggest the expression of COX-1 and COX-2 (show COX2 Antibodies) in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (show FAAH Antibodies)/Cox (show CPOX Antibodies) blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (show FAAH Antibodies)/cyclooxygenases (FAAH (show FAAH Antibodies), Cox-1, and Cox-2 (show COX2 Antibodies)) are overactive.
In arteries from non-insulin (show INS Antibodies)-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 (show PTGIR Antibodies) synthesis that evokes vasoconstrictor activity under the pathological condition.
specific inhibition of mmu-miR (show MLXIP Antibodies)-100-5p significantly enhanced expression of Il6 (show IL6 Antibodies), Ptgs1/2 and Tlr4 (show TLR4 Antibodies) mRNA
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and COX (show COX8A Antibodies) pathways.
The interactions of COX (show COX8A Antibodies)-1of rs3842787 and cox-2 (show COX2 Antibodies) of rs20417 were associated with aspirin resistance of stroke.
We provide the first report that pro-angiogenic genes PECAM1 (show PECAM1 Antibodies), PTGS1, FGD5 (show FGD5 Antibodies), and MCAM (show MCAM Antibodies) may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
a new neutrophil-activating platelet-derived lipid generated by COX-1 (show COX1 Antibodies) is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.
Seminal COX-1 (show COX1 Antibodies) is over-expressed in infertile oligoasthenoteratozoospermic (OAT (show OAT Antibodies)) men with varicocele (Vx) compared with fertile men with/without and infertile OAT (show OAT Antibodies) men without Vx being associated with oxidative stress, Vx grade and Vx laterality.
In Indian peptic ulcer hemorrhage patients, those with Cox-1 (show COX1 Antibodies) A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.
inverse allosteric regulation likely underlies the ability of PGHS-2 (show PTGS2 Antibodies) to operate at low AA concentrations, when PGHS-1 is effectively latent.
PON1 (show PON1 Antibodies), P2Y12 (show P2RY12 Antibodies) and COX1 (show COX1 Antibodies) polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 (show ALOX12 Antibodies) regulation.
Brain death increases the expression of COX-1 (show COX1 Antibodies) and COX-2 (show PTGS2 Antibodies) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (show PTGS2 Antibodies) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase