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The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Additionally we are shipping PROCR Kits (42) and PROCR Proteins (32) and many more products for this protein.
Showing 10 out of 154 products:
Human Monoclonal PROCR Primary Antibody for IF, IHC (p) - ABIN564600
Lee, Ku, Bae: Emodin-6-O-?-D-glucoside down-regulates endothelial protein C receptor shedding. in Archives of pharmacal research 2013
Show all 6 references for ABIN564600
Mouse (Murine) Monoclonal PROCR Primary Antibody for FACS - ABIN2657022
Balazs, Fabian, Esmon, Mulligan: Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. in Blood 2006
Show all 4 references for ABIN2657022
Mouse (Murine) Monoclonal PROCR Primary Antibody for ELISA (Capture), ELISpot - ABIN2662525
Kerschen, Hernandez, Zogg, Jia, Hessner, Fernandez, Griffin, Huettner, Castellino, Weiler: Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. in The Journal of clinical investigation 2010
Show all 4 references for ABIN2662525
Mouse (Murine) Monoclonal PROCR Primary Antibody for ICFC - ABIN2660823
Iwasaki, Arai, Kubota, Dahl, Suda: Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. in Blood 2010
Show all 4 references for ABIN2660823
Human Monoclonal PROCR Primary Antibody for IHC (fro) - ABIN1106043
Scheffer, Flens, Hageman, Izquierdo, Shoemaker, Scheper: Expression of the vascular endothelial cell protein C receptor in epithelial tumour cells. in European journal of cancer (Oxford, England : 1990) 2002
Show all 3 references for ABIN1106043
Human Polyclonal PROCR Primary Antibody for EIA, WB - ABIN452834
Nayak, Sen, Ghosh, Gopalakrishnan, Esmon, Pendurthi, Rao: Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. in Blood 2009
Show all 2 references for ABIN452834
Human Monoclonal PROCR Primary Antibody for BP, FACS - ABIN269970
Schut, Kirschbaum, Adelmeijer, de Groot, Lisman: In vitro uptake of recombinant factor VIIa by megakaryocytes with subsequent production of platelets containing functionally active drug. in British journal of haematology 2016
Human Polyclonal PROCR Primary Antibody for FACS, IHC (p) - ABIN389416
Menschikowski, Hagelgans, Eisenhofer, Siegert: Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways. in Experimental cell research 2009
data suggest that either the lack of the protective EPCR 4678C allele or the presence of EPCR 4600G allele may be associated with earlier development of thrombosis.
These data suggest that 6936A/G polymorphism is a risk factor for deep venous thrombosis and is associated with elevated plasma levels of soluble EPCR, while 4678G/C polymorphism plays a role in protection against deep venous thrombosis.
These data reveal a previously unknown functional heterogeneity in the interaction between Plasmodium falciparum PfEMP1 CIDRalpha1domain binding to EPCR and have major implications for understanding the distinct clinical pathologies of cerebral malaria.
Overall, these findings reveal a much greater complexity of how Plasmodium falciparum PfEMP1 CIDRalpha1 domain-expressing parasites may modulate malaria pathogenesis through EPCR adhesion.
In this Tanzanian population, neither PROCR haplotype nor level of soluble EPCR was associated with severe malaria.
Serum soluble EPCR is elevated in Alzheimer's disease. The degree of cognitive impairment is significantly correlated with serum sEPCR levels in Alzheimer's disease and mild cognitive impairment patients and healthy controls.
Report activation of protein C (show PROC Antibodies) and down-regulation of EPCR in trophobolasts stimulated with TNF-alpha (show TNF Antibodies).
This effect of EPCR may be dependent on PAR1 (show MARK2 Antibodies).
results did not conclusively identify a direct role of sEPCR in HSP, but our findings warrant further investigations, especially in severe HSP cases characterized by gastrointestinal bleeding or renal involvement
The degree of arteriovenous fistula stenosis was not correlated with serum EPCR
Thrombin (show F2 Antibodies)-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization. aPC (show APC Antibodies)-EPCR-PAR1 (show F2R Antibodies) signaling promotes HSC (show FUT1 Antibodies) retention in bone marrow.
impaired EPCR/protein C (show PROC Antibodies)-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
sPLA2 (show PLA2G2A Antibodies)-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C (show PROC Antibodies) activation.
HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.
The protein C (show PROC Antibodies) receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS (show TLR4 Antibodies))-regulated gene expression.
Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.
protein C (show PROC Antibodies) receptor (Procr), a novel Wnt (show WNT2 Antibodies) target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells
FVIIa binding to EPCR leads to a barrier protective effect in vivo
Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.
FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
protein C receptor, endothelial (EPCR)
, APC receptor
, CD201 antigen
, activated protein C receptor
, cell cycle, centrosome-associated protein
, endothelial protein C receptor
, endothelial cell protein C receptor
, CD antigen CD201
, centrosomal protein CCD41
, endothelial cell protein C/activated protein C