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Protein Interacting With Protein Kinase C, alpha 1 Proteins (PICK1)

The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Antibodies (116) and PICK1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PICK1 18693  
Rat PICK1 PICK1 84591 Q9EP80
PICK1 9463 Q9NRD5
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Top PICK1 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PICK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
,
Human , ,
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More Proteins for Protein Interacting With Protein Kinase C, alpha 1 (PICK1) Interaction Partners

Mouse (Murine) Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 Proteins)-Rep neuronal cells

  2. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

  3. results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.

  4. In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (show GRIA2 Proteins).

  5. This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.

  6. C-terminal domain of ICA69 (show ICA1 Proteins) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.

  7. we found that PICK1's expression in testis rescued the spermatogenic abnormalities and male infertility in Pick1 knockout mice. Our results indicate that the infertility is caused by the lack of PICK1 in the testis rather than in other organs.

  8. PICK1 is a critical DHHC8 (show ZDHHC8 Proteins) substrate whose palmitoylation is necessary for long-term depression

  9. PICK1 and ICA69 (show ICA1 Proteins) are key regulators of the formation and maturation of insulin (show INS Proteins) granules.

  10. PICK1, together with ICA69 (show ICA1 Proteins), is critical during budding of immature secretory vesicles from the trans-golgi network and thus for vesicular hormone storage.

Human Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention

  2. PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 Proteins)/3 complex.

  3. Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.

  4. Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.

  5. PICK1 promotes Ago2 (show EIF2C2 Proteins) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 Proteins) function in translational repression following neuronal stimulation.

  6. These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.

  7. C-terminal domain of ICA69 (show ICA1 Proteins) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.

  8. Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder.

  9. PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TGF-beta type I receptor (show TGFBR1 Proteins).

  10. The binding affinities of all major PICK1 interacting proteins are reported and the effects of PICK1 mutations on these interactions are described.

PICK1 Protein Profile

Protein Summary

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with PICK1

  • protein interacting with PRKCA 1 (PICK1)
  • protein interacting with C kinase 1 (Pick1)
  • protein interacting with PRKCA 1 (Pick1)
  • PICK protein
  • PRKCABP protein

Protein level used designations for PICK1

PRKCA-binding protein , protein kinase C, alpha binding protein , protein kinase C-alpha-binding protein , protein that interacts with C kinase 1 , protein interacting with C kinase 1

GENE ID SPECIES
100055023 Equus caballus
18693 Mus musculus
84591 Rattus norvegicus
9463 Homo sapiens
610191 Canis lupus familiaris
100158107 Sus scrofa
533737 Bos taurus
418030 Gallus gallus
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